IONIS PHARMACEUTICALS INC

Ticker: IONS CUSIP: 462222100 Class: COM

WORLDQUANT MILLENNIUM ADVISORS LLC's Holding History (CIK: 0001745981)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 17,410 Value ($000) $1,377 Avg Close $75.30 Range $64.93 - $83.61

Q2 2025

Shares 74,438 Value ($000) $2,941 Avg Close $32.73 Range $23.95 - $40.61

Q2 2021

Shares 251,075 Value ($000) $10,015 Avg Close $39.17 Range $34.43 - $47.87

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	17,410	$1,377	$75.30	$64.93 - $83.61
Q2 2025	74,438	$2,941	$32.73	$23.95 - $40.61
Q2 2021	251,075	$10,015	$39.17	$34.43 - $47.87