IONIS PHARMACEUTICALS INC

Ticker: IONS CUSIP: 462222100 Class: COM

Essex Savings Bank's Holding History (CIK: 0001752212)

Note: Option positions (PUT/CALL) are excluded.

Q2 2019

Shares 1,113 Value ($000) $71 Avg Close $70.69 Range $61.91 - $86.58

Q1 2019

Shares 633 Value ($000) $51 Avg Close $64.51 Range $52.45 - $81.59

Q4 2018

Shares 726 Value ($000) $39 Avg Close $51.00 Range $43.27 - $59.81

Period	Shares	Value ($000)	Average Close	Price Range
Q2 2019	1,113	$71	$70.69	$61.91 - $86.58
Q1 2019	633	$51	$64.51	$52.45 - $81.59
Q4 2018	726	$39	$51.00	$43.27 - $59.81