IONIS PHARMACEUTICALS INC

Ticker: IONS CUSIP: 462222100 Class: COM

Cresset Asset Management, LLC's Holding History (CIK: 0001761013)

Note: Option positions (PUT/CALL) are excluded.

Q1 2021

Shares 5,728 Value ($000) $258 Avg Close $55.77 Range $41.42 - $64.37

Q1 2019

Shares 865 Value ($000) $70 Avg Close $64.51 Range $52.45 - $81.59

Q4 2018

Shares 755 Value ($000) $41 Avg Close $51.00 Range $43.27 - $59.81

Period	Shares	Value ($000)	Average Close	Price Range
Q1 2021	5,728	$258	$55.77	$41.42 - $64.37
Q1 2019	865	$70	$64.51	$52.45 - $81.59
Q4 2018	755	$41	$51.00	$43.27 - $59.81