IONIS PHARMACEUTICALS INC

Ticker: IONS CUSIP: 462222100 Class: COM

Royal Fund Management, LLC's Holding History (CIK: 0001810099)

Note: Option positions (PUT/CALL) are excluded.

Q1 2020

Shares 10 Value ($000) $0 Avg Close $55.74 Range $39.32 - $64.34

Q4 2019

Shares 10 Value ($000) $0 Avg Close $59.58 Range $53.34 - $66.22

Q3 2019

Shares 10 Value ($000) $0 Avg Close $65.17 Range $58.48 - $73.09

Period	Shares	Value ($000)	Average Close	Price Range
Q1 2020	10	$0	$55.74	$39.32 - $64.34
Q4 2019	10	$0	$59.58	$53.34 - $66.22
Q3 2019	10	$0	$65.17	$58.48 - $73.09