IONIS PHARMACEUTICALS INC

Ticker: IONS CUSIP: 462222100 Class: COM

XTX Topco Ltd's Holding History (CIK: 0001828301)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 16,917 Value ($000) $1,338 Avg Close $75.30 Range $64.93 - $83.61

Q1 2025

Shares 12,404 Value ($000) $374 Avg Close $32.75 Range $29.61 - $35.48

Q4 2024

Shares 25,362 Value ($000) $887 Avg Close $37.38 Range $33.33 - $40.58

Q3 2024

Shares 16,805 Value ($000) $673 Avg Close $46.53 Range $39.48 - $52.34

Q1 2024

Shares 8,585 Value ($000) $372 Avg Close $47.67 Range $41.60 - $54.44

Q3 2023

Shares 16,352 Value ($000) $742 Avg Close $41.26 Range $38.26 - $47.72

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	16,917	$1,338	$75.30	$64.93 - $83.61
Q1 2025	12,404	$374	$32.75	$29.61 - $35.48
Q4 2024	25,362	$887	$37.38	$33.33 - $40.58
Q3 2024	16,805	$673	$46.53	$39.48 - $52.34
Q1 2024	8,585	$372	$47.67	$41.60 - $54.44
Q3 2023	16,352	$742	$41.26	$38.26 - $47.72