IONIS PHARMACEUTICALS INC

Ticker: IONS CUSIP: 462222100 Class: COM

Polar Capital Holdings Plc's Holding History (CIK: 0001837309)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 1,333,424 Value ($000) $105,487 Avg Close $75.30 Range $64.93 - $83.61

Q3 2025

Shares 1,033,622 Value ($000) $67,620 Avg Close $48.82 Range $39.72 - $65.55

Q2 2025

Shares 1,000,000 Value ($000) $39,510 Avg Close $32.73 Range $23.95 - $40.61

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	1,333,424	$105,487	$75.30	$64.93 - $83.61
Q3 2025	1,033,622	$67,620	$48.82	$39.72 - $65.55
Q2 2025	1,000,000	$39,510	$32.73	$23.95 - $40.61