IONIS PHARMACEUTICALS INC

Ticker: IONS CUSIP: 462222100 Class: COM

Nuveen, LLC's Holding History (CIK: 0001871926)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 660,769 Value ($000) $52,273 Avg Close $75.30 Range $64.93 - $83.61

Q3 2025

Shares 415,618 Value ($000) $27,190 Avg Close $48.82 Range $39.72 - $65.55

Q2 2025

Shares 245,085 Value ($000) $9,683 Avg Close $32.73 Range $23.95 - $40.61

Q1 2025

Shares 308,777 Value ($000) $9,316 Avg Close $32.75 Range $29.61 - $35.48

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	660,769	$52,273	$75.30	$64.93 - $83.61
Q3 2025	415,618	$27,190	$48.82	$39.72 - $65.55
Q2 2025	245,085	$9,683	$32.73	$23.95 - $40.61
Q1 2025	308,777	$9,316	$32.75	$29.61 - $35.48