IONIS PHARMACEUTICALS INC

Ticker: IONS CUSIP: 462222100 Class: COM

Significant Wealth Partners LLC's Holding History (CIK: 0001964680)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 6,764 Value ($000) $535 Avg Close $75.30 Range $64.93 - $83.61

Q3 2025

Shares 14,967 Value ($000) $979 Avg Close $48.82 Range $39.72 - $65.55

Q2 2025

Shares 15,504 Value ($000) $613 Avg Close $32.73 Range $23.95 - $40.61

Q1 2025

Shares 13,605 Value ($000) $410 Avg Close $32.75 Range $29.61 - $35.48

Q4 2024

Shares 10,905 Value ($000) $381 Avg Close $37.38 Range $33.33 - $40.58

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	6,764	$535	$75.30	$64.93 - $83.61
Q3 2025	14,967	$979	$48.82	$39.72 - $65.55
Q2 2025	15,504	$613	$32.73	$23.95 - $40.61
Q1 2025	13,605	$410	$32.75	$29.61 - $35.48
Q4 2024	10,905	$381	$37.38	$33.33 - $40.58