IONIS PHARMACEUTICALS INC

Ticker: IONS CUSIP: 462222100 Class: COM

Susquehanna Portfolio Strategies, LLC's Holding History (CIK: 0001996449)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 95,960 Value ($000) $7,591 Avg Close $75.30 Range $64.93 - $83.61

Q3 2025

Shares 95,960 Value ($000) $6,278 Avg Close $48.82 Range $39.72 - $65.55

Q2 2025

Shares 92,900 Value ($000) $3,670 Avg Close $32.73 Range $23.95 - $40.61

Q3 2024

Shares 10,894 Value ($000) $436 Avg Close $46.53 Range $39.48 - $52.34

Q2 2024

Shares 43,028 Value ($000) $2,051 Avg Close $41.01 Range $35.95 - $47.86

Q1 2024

Shares 130,986 Value ($000) $5,678 Avg Close $47.67 Range $41.60 - $54.44

Q4 2023

Shares 169,678 Value ($000) $8,584 Avg Close $47.90 Range $41.84 - $52.27

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	95,960	$7,591	$75.30	$64.93 - $83.61
Q3 2025	95,960	$6,278	$48.82	$39.72 - $65.55
Q2 2025	92,900	$3,670	$32.73	$23.95 - $40.61
Q3 2024	10,894	$436	$46.53	$39.48 - $52.34
Q2 2024	43,028	$2,051	$41.01	$35.95 - $47.86
Q1 2024	130,986	$5,678	$47.67	$41.60 - $54.44
Q4 2023	169,678	$8,584	$47.90	$41.84 - $52.27