IONIS PHARMACEUTICALS INC

Ticker: IONS CUSIP: 462222100 Class: COM

TD Waterhouse Canada Inc.'s Holding History (CIK: 0001999606)

Note: Option positions (PUT/CALL) are excluded.

Q3 2022

Shares 100 Value ($000) $4 Avg Close $42.14 Range $35.95 - $48.82

Q2 2022

Shares 100 Value ($000) $4 Avg Close $37.71 Range $31.46 - $44.42

Q1 2022

Shares 100 Value ($000) $4 Avg Close $32.73 Range $28.25 - $37.15

Q4 2021

Shares 100 Value ($000) $3 Avg Close $31.48 Range $25.04 - $35.80

Period	Shares	Value ($000)	Average Close	Price Range
Q3 2022	100	$4	$42.14	$35.95 - $48.82
Q2 2022	100	$4	$37.71	$31.46 - $44.42
Q1 2022	100	$4	$32.73	$28.25 - $37.15
Q4 2021	100	$3	$31.48	$25.04 - $35.80