IONIS PHARMACEUTICALS INC

Ticker: IONS CUSIP: 462222100 Class: COM

BlackRock, Inc.'s Holding History (CIK: 0002012383)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 10,647,863 Value ($000) $842,352 Avg Close $75.30 Range $64.93 - $83.61

Q3 2025

Shares 10,447,940 Value ($000) $683,504 Avg Close $48.82 Range $39.72 - $65.55

Q2 2025

Shares 10,896,937 Value ($000) $430,538 Avg Close $32.73 Range $23.95 - $40.61

Q1 2025

Shares 11,264,442 Value ($000) $339,848 Avg Close $32.75 Range $29.61 - $35.48

Q4 2024

Shares 11,665,548 Value ($000) $407,828 Avg Close $37.38 Range $33.33 - $40.58

Q3 2024

Shares 10,813,023 Value ($000) $433,170 Avg Close $46.53 Range $39.48 - $52.34

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	10,647,863	$842,352	$75.30	$64.93 - $83.61
Q3 2025	10,447,940	$683,504	$48.82	$39.72 - $65.55
Q2 2025	10,896,937	$430,538	$32.73	$23.95 - $40.61
Q1 2025	11,264,442	$339,848	$32.75	$29.61 - $35.48
Q4 2024	11,665,548	$407,828	$37.38	$33.33 - $40.58
Q3 2024	10,813,023	$433,170	$46.53	$39.48 - $52.34