IONIS PHARMACEUTICALS INC

Ticker: IONS CUSIP: 462222100 Class: COM

Orion Investment Co's Holding History (CIK: 0002033920)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 225,161 Value ($000) $17,812 Avg Close $75.30 Range $64.93 - $83.61

Q3 2025

Shares 224,705 Value ($000) $14,700 Avg Close $48.82 Range $39.72 - $65.55

Q2 2025

Shares 217,370 Value ($000) $8,588 Avg Close $32.73 Range $23.95 - $40.61

Q1 2025

Shares 215,290 Value ($000) $6,495 Avg Close $32.75 Range $29.61 - $35.48

Q4 2024

Shares 216,000 Value ($000) $7,551 Avg Close $37.38 Range $33.33 - $40.58

Q3 2024

Shares 218,525 Value ($000) $8,754 Avg Close $46.53 Range $39.48 - $52.34

Q2 2024

Shares 218,570 Value ($000) $10,417 Avg Close $41.01 Range $35.95 - $47.86

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	225,161	$17,812	$75.30	$64.93 - $83.61
Q3 2025	224,705	$14,700	$48.82	$39.72 - $65.55
Q2 2025	217,370	$8,588	$32.73	$23.95 - $40.61
Q1 2025	215,290	$6,495	$32.75	$29.61 - $35.48
Q4 2024	216,000	$7,551	$37.38	$33.33 - $40.58
Q3 2024	218,525	$8,754	$46.53	$39.48 - $52.34
Q2 2024	218,570	$10,417	$41.01	$35.95 - $47.86