IONIS PHARMACEUTICALS INC

Ticker: IONS CUSIP: 462222100 Class: COM

TEMA ETFS LLC's Holding History (CIK: 0002056807)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 8,557 Value ($000) $677 Avg Close $75.30 Range $64.93 - $83.61

Q3 2025

Shares 12,306 Value ($000) $805 Avg Close $48.82 Range $39.72 - $65.55

Q2 2025

Shares 28,161 Value ($000) $1,113 Avg Close $32.73 Range $23.95 - $40.61

Q1 2025

Shares 25,141 Value ($000) $759 Avg Close $32.75 Range $29.61 - $35.48

Q4 2024

Shares 56,844 Value ($000) $1,987 Avg Close $37.38 Range $33.33 - $40.58

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	8,557	$677	$75.30	$64.93 - $83.61
Q3 2025	12,306	$805	$48.82	$39.72 - $65.55
Q2 2025	28,161	$1,113	$32.73	$23.95 - $40.61
Q1 2025	25,141	$759	$32.75	$29.61 - $35.48
Q4 2024	56,844	$1,987	$37.38	$33.33 - $40.58