IONIS PHARMACEUTICALS INC

Ticker: IONS CUSIP: 462222100 Class: COM

Universal- Beteiligungs- und Servicegesellschaft mbH's Holding History (CIK: 0002057170)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 219,574 Value ($000) $17,371 Avg Close $75.30 Range $64.93 - $83.61

Q3 2025

Shares 197,434 Value ($000) $12,916 Avg Close $48.82 Range $39.72 - $65.55

Q2 2025

Shares 149,839 Value ($000) $5,920 Avg Close $32.73 Range $23.95 - $40.61

Q1 2025

Shares 143,870 Value ($000) $4,341 Avg Close $32.75 Range $29.61 - $35.48

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	219,574	$17,371	$75.30	$64.93 - $83.61
Q3 2025	197,434	$12,916	$48.82	$39.72 - $65.55
Q2 2025	149,839	$5,920	$32.73	$23.95 - $40.61
Q1 2025	143,870	$4,341	$32.75	$29.61 - $35.48