IOVANCE BIOTHERAPEUTICS INC

Ticker: IOVA CUSIP: 462260100 Class: COM

SPHERA FUNDS MANAGEMENT LTD.'s Holding History (CIK: 0001496201)

Note: Option positions (PUT/CALL) are excluded.

Q4 2021

Shares 281,769 Value ($000) $5,379 Avg Close $22.02 Range $15.94 - $27.96

Q3 2021

Shares 494,809 Value ($000) $12,202 Avg Close $23.56 Range $20.19 - $27.01

Q2 2021

Shares 378,642 Value ($000) $9,852 Avg Close $25.99 Range $15.88 - $33.99

Q4 2020

Shares 127,289 Value ($000) $5,906 Avg Close $39.70 Range $24.67 - $52.43

Q3 2020

Shares 253,000 Value ($000) $8,329 Avg Close $30.66 Range $26.75 - $36.93

Q2 2020

Shares 348,000 Value ($000) $9,553 Avg Close $32.88 Range $26.34 - $41.49

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2021	281,769	$5,379	$22.02	$15.94 - $27.96
Q3 2021	494,809	$12,202	$23.56	$20.19 - $27.01
Q2 2021	378,642	$9,852	$25.99	$15.88 - $33.99
Q4 2020	127,289	$5,906	$39.70	$24.67 - $52.43
Q3 2020	253,000	$8,329	$30.66	$26.75 - $36.93
Q2 2020	348,000	$9,553	$32.88	$26.34 - $41.49