ISHARES

CUSIP: 464286848 Class: COM

Novo Holdings A/S's Holding History (CIK: 0001388325)

Note: Option positions (PUT/CALL) are excluded.

Q3 2011
Shares 700,000 Value ($000) $6,622 Avg Close — Range —
Q2 2011
Shares 700,000 Value ($000) $7,301 Avg Close — Range —
Q1 2011
Shares 700,000 Value ($000) $7,221 Avg Close — Range —
Q4 2010
Shares 700,000 Value ($000) $7,637 Avg Close — Range —
Q3 2010
Shares 700,000 Value ($000) $6,920 Avg Close — Range —
Q2 2010
Shares 700,000 Value ($000) $6,440 Avg Close — Range —
Q1 2010
Shares 700,000 Value ($000) $7,308 Avg Close — Range —
Q4 2009
Shares 700,000 Value ($000) $6,818 Avg Close — Range —