ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

VANGUARD GROUP INC's Holding History (CIK: 0000102909)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 8,807,776 Value ($000) $356,009 Avg Close — Range —
Q2 2015
Shares 8,580,350 Value ($000) $493,799 Avg Close — Range —
Q1 2015
Shares 8,013,026 Value ($000) $510,189 Avg Close — Range —
Q4 2014
Shares 7,271,871 Value ($000) $448,965 Avg Close — Range —
Q3 2014
Shares 7,257,516 Value ($000) $281,809 Avg Close — Range —
Q2 2014
Shares 7,269,544 Value ($000) $250,436 Avg Close — Range —
Q1 2014
Shares 7,786,346 Value ($000) $336,448 Avg Close — Range —
Q4 2013
Shares 7,681,946 Value ($000) $306,049 Avg Close — Range —
Q3 2013
Shares 7,335,712 Value ($000) $275,383 Avg Close — Range —
Q2 2013
Shares 6,701,309 Value ($000) $180,064 Avg Close — Range —