ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

GROUP ONE TRADING, L.P.'s Holding History (CIK: 0000932540)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 162,159 Value ($000) $6,554 Avg Close — Range —
Q2 2015
Shares 165,926 Value ($000) $9,549 Avg Close — Range —
Q1 2015
Shares 113,807 Value ($000) $7,246 Avg Close — Range —
Q4 2014
Shares 79,125 Value ($000) $4,885 Avg Close — Range —
Q3 2014
Shares 88,030 Value ($000) $3,418 Avg Close — Range —
Q2 2014
Shares 59,626 Value ($000) $2,054 Avg Close — Range —
Q1 2014
Shares 46,323 Value ($000) $2,002 Avg Close — Range —
Q3 2013
Shares 3,994 Value ($000) $150 Avg Close — Range —
Q2 2013
Shares 41,854 Value ($000) $1,125 Avg Close — Range —