ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

ROYAL BANK OF CANADA's Holding History (CIK: 0001000275)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 194,686 Value ($000) $7,869 Avg Close — Range —
Q2 2015
Shares 364,561 Value ($000) $20,981 Avg Close — Range —
Q1 2015
Shares 452,941 Value ($000) $28,839 Avg Close — Range —
Q4 2014
Shares 527,032 Value ($000) $32,539 Avg Close — Range —
Q3 2014
Shares 589,090 Value ($000) $22,875 Avg Close — Range —
Q2 2014
Shares 160,735 Value ($000) $5,537 Avg Close — Range —
Q1 2014
Shares 100,986 Value ($000) $4,364 Avg Close — Range —
Q4 2013
Shares 60,966 Value ($000) $2,428 Avg Close — Range —
Q3 2013
Shares 29,823 Value ($000) $1,120 Avg Close — Range —
Q2 2013
Shares 23,405 Value ($000) $629 Avg Close — Range —