ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

RENAISSANCE TECHNOLOGIES LLC's Holding History (CIK: 0001037389)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 476,814 Value ($000) $19,273 Avg Close — Range —
Q2 2015
Shares 51,314 Value ($000) $2,953 Avg Close — Range —
Q1 2014
Shares 136,914 Value ($000) $5,916 Avg Close — Range —
Q4 2013
Shares 326,114 Value ($000) $12,992 Avg Close — Range —
Q3 2013
Shares 328,914 Value ($000) $12,347 Avg Close — Range —
Q2 2013
Shares 27,914 Value ($000) $750 Avg Close — Range —