ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

COMMONWEALTH OF PENNSYLVANIA PUBLIC SCHOOL EMPLS RETRMT SYS's Holding History (CIK: 0001083190)

Note: Option positions (PUT/CALL) are excluded.

Q4 2014
Shares 12,665 Value ($000) $782 Avg Close — Range —
Q3 2014
Shares 12,485 Value ($000) $485 Avg Close — Range —
Q4 2013
Shares 17,065 Value ($000) $680 Avg Close — Range —