ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

RHUMBLINE ADVISERS's Holding History (CIK: 0001115418)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 128,583 Value ($000) $5,197 Avg Close — Range —
Q2 2015
Shares 125,805 Value ($000) $7,240 Avg Close — Range —
Q1 2015
Shares 130,761 Value ($000) $8,326 Avg Close — Range —
Q4 2014
Shares 111,711 Value ($000) $6,897 Avg Close — Range —
Q3 2014
Shares 114,948 Value ($000) $4,463 Avg Close — Range —
Q2 2014
Shares 116,873 Value ($000) $4,026 Avg Close — Range —
Q1 2014
Shares 119,595 Value ($000) $5,168 Avg Close — Range —
Q4 2013
Shares 124,555 Value ($000) $4,962 Avg Close — Range —
Q3 2013
Shares 118,365 Value ($000) $4,443 Avg Close — Range —
Q2 2013
Shares 118,768 Value ($000) $3,191 Avg Close — Range —