ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

SPHERA FUNDS MANAGEMENT LTD.'s Holding History (CIK: 0001496201)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 68,000 Value ($000) $2,749 Avg Close — Range —
Q2 2015
Shares 48,000 Value ($000) $2,762 Avg Close — Range —
Q4 2013
Shares 30,000 Value ($000) $1,195 Avg Close — Range —