PERSPECTIVE THERAPEUTICS INC

Institution	Shares	Value ($000)
Opaleye Management Inc.	1,184,500	$4,990
DAFNA Capital Management LLC	50,000	$138
Caitong International Asset Management Co., Ltd	30,627	$84
ADAR1 Capital Management, LLC	95,193	$262
Massar Capital Management, LP	52,000	$143
R Squared Ltd	15,991	$44
RENAISSANCE TECHNOLOGIES LLC	352,493	$969
MARSHALL WACE, LLP	406,732	$1,119
GSA CAPITAL PARTNERS LLP	86,212	$0
Aigen Investment Management, LP	10,173	$28
Schonfeld Strategic Advisors LLC	62,370	$172
DIMENSIONAL FUND ADVISORS LP	91,557	$252
Engineers Gate Manager LP	12,562	$35
AMERICAN CENTURY COMPANIES INC	12,567	$35
RAYMOND JAMES FINANCIAL INC	10,730	$30
GROUP ONE TRADING, L.P.	3,769	$10
GAMMA Investing LLC	195	$1
INTERNATIONAL ASSETS INVESTMENT MANAGEMENT, LLC	90	$0
NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO	36	$0
ROTHSCHILD INVESTMENT LLC	7	$0

Increased Positions (27)

Avidity Partners Management LP

Value ($000) $8,830 (-14.0%) Shares 3,210,733 (+7.2%)

Patient Square Capital LP

Value ($000) $3,115 (+160.0%) Shares 1,132,815 (+224.3%)

Trueblood Wealth Management, LLC

Value ($000) $327 (+38.2%) Shares 119,061 (+72.4%)

nVerses Capital, LLC

Value ($000) $31 (-45.3%) Shares 11,420 (+165.6%)

Taylor & Morgan Wealth Management, LLC

Value ($000) $267 (-14.5%) Shares 97,000 (+6.6%)

TWO SIGMA INVESTMENTS, LP

Value ($000) $3,296 (+84.9%) Shares 1,198,644 (+130.7%)

MORGAN STANLEY

Value ($000) $12,305 (+29.9%) Shares 4,474,522 (+62.1%)

TWO SIGMA ADVISERS, LP

Value ($000) $1,826 (+31.2%) Shares 663,830 (+63.7%)

Point72 Asset Management, L.P.

Value ($000) $864 (+469.5%) Shares 314,180 (+610.3%)

UBS Group AG

Value ($000) $2,547 (+15.8%) Shares 926,331 (+44.5%)

BlackRock, Inc.

Value ($000) $12,540 (-16.3%) Shares 4,559,977 (+4.4%)

Graham Capital Management, L.P.

Value ($000) $221 (+41.8%) Shares 80,193 (+76.8%)

XTX Topco Ltd

Value ($000) $227 (+9.5%) Shares 82,476 (+36.5%)

CITADEL ADVISORS LLC

Value ($000) $744 (+35.0%) Shares 270,491 (+68.4%)

VANGUARD GROUP INC

Value ($000) $9,599 (-18.6%) Shares 3,490,658 (+1.5%)

STATE STREET CORP

Value ($000) $3,138 (-17.2%) Shares 1,141,247 (+3.3%)

SUSQUEHANNA INTERNATIONAL GROUP, LLP

Value ($000) $224 (+27.3%) Shares 81,441 (+58.7%)

WELLS FARGO & COMPANY/MN

Value ($000) $184 (+17.2%) Shares 66,820 (+46.2%)

FEDERATED HERMES, INC.

Value ($000) $588 (-13.5%) Shares 213,759 (+7.9%)

AXQ CAPITAL, LP

Value ($000) $35 (-0.5%) Shares 12,749 (+24.2%)

Institution	Prev Shares	Curr Shares	Change
Avidity Partners Management LP	2,994,033	3,210,733	+216,700 (+7.2%)
Patient Square Capital LP	349,323	1,132,815	+783,492 (+224.3%)
Trueblood Wealth Management, LLC	69,061	119,061	+50,000 (+72.4%)
nVerses Capital, LLC	4,300	11,420	+7,120 (+165.6%)
Taylor & Morgan Wealth Management, LLC	91,000	97,000	+6,000 (+6.6%)
TWO SIGMA INVESTMENTS, LP	519,668	1,198,644	+678,976 (+130.7%)
MORGAN STANLEY	2,760,861	4,474,522	+1,713,661 (+62.1%)
TWO SIGMA ADVISERS, LP	405,630	663,830	+258,200 (+63.7%)
Point72 Asset Management, L.P.	44,233	314,180	+269,947 (+610.3%)
UBS Group AG	641,143	926,331	+285,188 (+44.5%)
BlackRock, Inc.	4,366,577	4,559,977	+193,400 (+4.4%)
Graham Capital Management, L.P.	45,357	80,193	+34,836 (+76.8%)
XTX Topco Ltd	60,402	82,476	+22,074 (+36.5%)
CITADEL ADVISORS LLC	160,661	270,491	+109,830 (+68.4%)
VANGUARD GROUP INC	3,437,865	3,490,658	+52,793 (+1.5%)
STATE STREET CORP	1,104,704	1,141,247	+36,543 (+3.3%)
SUSQUEHANNA INTERNATIONAL GROUP, LLP	51,304	81,441	+30,137 (+58.7%)
WELLS FARGO & COMPANY/MN	45,695	66,820	+21,125 (+46.2%)
FEDERATED HERMES, INC.	198,191	213,759	+15,568 (+7.9%)
AXQ CAPITAL, LP	10,268	12,749	+2,481 (+24.2%)

Decreased Positions (34)

SPHERA FUNDS MANAGEMENT LTD.

Value ($000) $962 (-45.0%) Shares 349,973 (-31.4%)

SHERBROOKE PARK ADVISERS LLC

Value ($000) $45 (-59.9%) Shares 16,232 (-49.9%)

Hills Bank & Trust Co

Value ($000) $2,580 (-23.2%) Shares 938,200 (-4.2%)

FMR LLC

Value ($000) $844 (-97.5%) Shares 307,055 (-96.9%)

MILLENNIUM MANAGEMENT LLC

Value ($000) $3,868 (-56.0%) Shares 1,406,374 (-45.1%)

Walleye Capital LLC

Value ($000) $904 (-51.7%) Shares 328,667 (-39.8%)

JPMORGAN CHASE & CO

Value ($000) $77 (-94.8%) Shares 28,034 (-93.6%)

BANK OF AMERICA CORP /DE/

Value ($000) $1,167 (-56.7%) Shares 424,519 (-46.0%)

BNP PARIBAS ARBITRAGE, SA

Value ($000) $34 (-90.3%) Shares 12,510 (-87.9%)

JANE STREET GROUP, LLC

Value ($000) $726 (-35.8%) Shares 263,995 (-19.9%)

BARCLAYS PLC

Value ($000) $255 (-83.2%) Shares 92,791 (-18.7%)

CITIGROUP INC

Value ($000) $206 (-52.0%) Shares 75,041 (-40.1%)

GOLDMAN SACHS GROUP INC

Value ($000) $440 (-35.2%) Shares 159,837 (-19.2%)

Nuveen, LLC

Value ($000) $3,504 (-21.9%) Shares 1,274,007 (-2.6%)

NORTHERN TRUST CORP

Value ($000) $1,208 (-25.2%) Shares 439,214 (-6.7%)

GEODE CAPITAL MANAGEMENT, LLC

Value ($000) $3,891 (-20.8%) Shares 1,414,522 (-1.3%)

MetLife Investment Management, LLC

Value ($000) $46 (-54.7%) Shares 16,717 (-43.4%)

ROYAL BANK OF CANADA

Value ($000) $16 (-70.4%) Shares 5,939 (-62.4%)

RHUMBLINE ADVISERS

Value ($000) $211 (-27.6%) Shares 76,571 (-9.7%)

NISA INVESTMENT ADVISORS, LLC

Value ($000) $0 (-97.6%) Shares 140 (-97.0%)

Institution	Prev Shares	Curr Shares	Change
SPHERA FUNDS MANAGEMENT LTD.	510,343	349,973	-160,370 (-31.4%)
SHERBROOKE PARK ADVISERS LLC	32,425	16,232	-16,193 (-49.9%)
Hills Bank & Trust Co	979,200	938,200	-41,000 (-4.2%)
FMR LLC	10,010,865	307,055	-9,703,810 (-96.9%)
MILLENNIUM MANAGEMENT LLC	2,561,112	1,406,374	-1,154,738 (-45.1%)
Walleye Capital LLC	546,033	328,667	-217,366 (-39.8%)
JPMORGAN CHASE & CO	436,357	28,034	-408,323 (-93.6%)
BANK OF AMERICA CORP /DE/	785,823	424,519	-361,304 (-46.0%)
BNP PARIBAS ARBITRAGE, SA	103,736	12,510	-91,226 (-87.9%)
JANE STREET GROUP, LLC	329,673	263,995	-65,678 (-19.9%)
BARCLAYS PLC	114,075	92,791	-21,284 (-18.7%)
CITIGROUP INC	125,308	75,041	-50,267 (-40.1%)
GOLDMAN SACHS GROUP INC	197,710	159,837	-37,873 (-19.2%)
Nuveen, LLC	1,308,642	1,274,007	-34,635 (-2.6%)
NORTHERN TRUST CORP	470,960	439,214	-31,746 (-6.7%)
GEODE CAPITAL MANAGEMENT, LLC	1,432,487	1,414,522	-17,965 (-1.3%)
MetLife Investment Management, LLC	29,559	16,717	-12,842 (-43.4%)
ROYAL BANK OF CANADA	15,797	5,939	-9,858 (-62.4%)
RHUMBLINE ADVISERS	84,805	76,571	-8,234 (-9.7%)
NISA INVESTMENT ADVISORS, LLC	4,739	140	-4,599 (-97.0%)

Exited Positions (10)

Rock Springs Capital Management LP

Value ($000) $1,524 Shares 444,383

Atom Investors LP

Value ($000) $58 Shares 16,815

CITIZENS FINANCIAL GROUP INC/RI

Value ($000) $182 Shares 53,100

WELLINGTON MANAGEMENT GROUP LLP

Value ($000) $709 Shares 206,632

Mariner, LLC

Value ($000) $295 Shares 86,116

Quadrature Capital Ltd

Value ($000) $84 Shares 24,221

LOS ANGELES CAPITAL MANAGEMENT LLC

Value ($000) $60 Shares 17,595

Advisory Services Network, LLC

Value ($000) $0 Shares 67

Wealthspire Advisors, LLC

Value ($000) $0 Shares 40

SG Americas Securities, LLC

Value ($000) $0 Shares 13,538

Institution	Prev Shares	Prev Value ($000)
Rock Springs Capital Management LP	444,383	$1,524
Atom Investors LP	16,815	$58
CITIZENS FINANCIAL GROUP INC/RI	53,100	$182
WELLINGTON MANAGEMENT GROUP LLP	206,632	$709
Mariner, LLC	86,116	$295
Quadrature Capital Ltd	24,221	$84
LOS ANGELES CAPITAL MANAGEMENT LLC	17,595	$60
Advisory Services Network, LLC	67	$0
Wealthspire Advisors, LLC	40	$0
SG Americas Securities, LLC	13,538	$0