KARYOPHARM THERAPEUTICS INC

CUSIP: 48576U106 Class: Common Stock

SPHERA FUNDS MANAGEMENT LTD.'s Holding History (CIK: 0001496201)

Note: Option positions (PUT/CALL) are excluded.

Q2 2020
Shares 392,831 Value ($000) $7,440 Avg Close — Range —
Q1 2020
Shares 550,000 Value ($000) $10,566 Avg Close — Range —
Q4 2019
Shares 330,000 Value ($000) $6,326 Avg Close — Range —