KARYOPHARM THERAPEUTICS INC

Ticker: KPTI CUSIP: 48576U205 Class: 0

ADAGE CAPITAL PARTNERS GP, L.L.C.'s Holding History (CIK: 0001165408)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 421,322 Value ($000) $3,101 Avg Close $6.12 Range $4.51 - $7.70

Q3 2025

Shares 421,322 Value ($000) $2,755 Avg Close $5.38 Range $3.65 - $8.15

Q2 2025

Shares 421,322 Value ($000) $1,816 Avg Close $4.91 Range $3.51 - $7.90

Q1 2025

Shares 421,322 Value ($000) $1,576 Avg Close $8.54 Range $3.73 - $12.45

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	421,322	$3,101	$6.12	$4.51 - $7.70
Q3 2025	421,322	$2,755	$5.38	$3.65 - $8.15
Q2 2025	421,322	$1,816	$4.91	$3.51 - $7.90
Q1 2025	421,322	$1,576	$8.54	$3.73 - $12.45