| Opaleye Management Inc. | 930,000 | $6,845 |
| Affinity Asset Advisors, LLC | 889,575 | $6,547 |
| T. Rowe Price Investment Management, Inc. | 585,908 | $4 |
| VANGUARD GROUP INC | 559,619 | $4,119 |
| Ikarian Capital, LLC | 544,554 | $4,008 |
| Soleus Capital Management, L.P. | 440,000 | $3,238 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 421,322 | $3,101 |
| DAVIDSON KEMPNER CAPITAL MANAGEMENT LP | 310,020 | $2,282 |
| BRAIDWELL LP | 303,370 | $2,233 |
| Exome Asset Management LLC | 295,541 | $2,175 |
| AMERIPRISE FINANCIAL INC | 276,881 | $2,038 |
| Boxer Capital Management, LLC | 252,536 | $1,859 |
| BlackRock, Inc. | 247,558 | $1,822 |
| GEODE CAPITAL MANAGEMENT, LLC | 187,734 | $1,382 |
| TWO SIGMA INVESTMENTS, LP | 148,793 | $1,095 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 147,698 | $1,087 |
| BOOTHBAY FUND MANAGEMENT, LLC | 144,628 | $1,064 |
| Catalio Capital Management, LP | 142,984 | $1,052 |
| Avidity Partners Management LP | 134,566 | $990 |
| MARSHALL WACE, LLP | 128,451 | $945 |
| GROUP ONE TRADING, L.P. | 102,419 | $754 |
| C WorldWide Group Holding A/S | 100,000 | $1 |
| Walleye Capital LLC | 95,672 | $704 |
| TWO SIGMA ADVISERS, LP | 89,729 | $660 |
| UBS Group AG | 88,455 | $651 |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 65,873 | $485 |
| Context Capital Management, LLC | 62,995 | $464 |
| RENAISSANCE TECHNOLOGIES LLC | 59,914 | $441 |
| Quadrature Capital Ltd | 59,708 | $439 |
| STATE STREET CORP | 58,942 | $434 |
| ROYAL BANK OF CANADA | 58,000 | $427 |
| Connor, Clark & Lunn Investment Management Ltd. | 57,212 | $421 |
| Jump Financial, LLC | 53,816 | $396 |
| DAFNA Capital Management LLC | 51,000 | $375 |
| ADAR1 Capital Management, LLC | 50,000 | $368 |
| BANK OF AMERICA CORP /DE/ | 48,088 | $354 |
| Trexquant Investment LP | 41,733 | $307 |
| SILVERBACK ASSET MANAGEMENT LLC | 40,000 | $294 |
| JANE STREET GROUP, LLC | 35,533 | $262 |
| SIMPLEX TRADING, LLC | 32,868 | $242 |
| CITADEL ADVISORS LLC | 31,709 | $233 |
| NORTHERN TRUST CORP | 29,023 | $214 |
| PRELUDE CAPITAL MANAGEMENT, LLC | 28,723 | $211 |
| Baird Financial Group, Inc. | 27,993 | $206 |
| Persistent Asset Partners Ltd | 18,316 | $135 |
| TUDOR INVESTMENT CORP ET AL | 12,922 | $95 |
| XTX Topco Ltd | 11,904 | $88 |
| Bank of New York Mellon Corp | 11,087 | $82 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 10,886 | $0 |
| Corient Private Wealth LLC | 10,039 | $10 |
| MORGAN STANLEY | 8,858 | $65 |
| BARCLAYS PLC | 4,109 | $30 |
| ACADIAN ASSET MANAGEMENT LLC | 3,726 | $0 |
| TD Waterhouse Canada Inc. | 3,203 | $24 |
| JPMORGAN CHASE & CO | 1,741 | $13 |
| Rockefeller Capital Management L.P. | 733 | $5 |
| FMR LLC | 679 | $5 |
| Aspect Partners, LLC | 391 | $3 |
| OSAIC HOLDINGS, INC. | 282 | $2 |
| Quent Capital, LLC | 235 | $2 |
| MB, LEVIS & ASSOCIATES, LLC | 100 | $1 |
| HARBOUR INVESTMENTS, INC. | 85 | $1 |
| BNP PARIBAS ARBITRAGE, SA | 82 | $1 |
| SBI Securities Co., Ltd. | 74 | $1 |
| Activest Wealth Management | 66 | $0 |
| Allworth Financial LP | 26 | $0 |
| CIBC Private Wealth Group, LLC | 3 | $0 |
| West Branch Capital LLC | 3 | $0 |
| CITIGROUP INC | 1 | $0 |