KARYOPHARM THERAPEUTICS INC

Ticker: KPTI CUSIP: 48576U205 Class: 0

Avidity Partners Management LP's Holding History (CIK: 0001791827)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 134,566 Value ($000) $990 Avg Close $6.12 Range $4.51 - $7.70

Q3 2025

Shares 134,566 Value ($000) $880 Avg Close $5.38 Range $3.65 - $8.15

Q2 2025

Shares 134,566 Value ($000) $580 Avg Close $4.91 Range $3.51 - $7.90

Q1 2025

Shares 134,566 Value ($000) $503 Avg Close $8.54 Range $3.73 - $12.45

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	134,566	$990	$6.12	$4.51 - $7.70
Q3 2025	134,566	$880	$5.38	$3.65 - $8.15
Q2 2025	134,566	$580	$4.91	$3.51 - $7.90
Q1 2025	134,566	$503	$8.54	$3.73 - $12.45