| Atlas Venture Life Science Advisors, LLC | 1,137,149 | $9,109 |
| NEA Management Company, LLC | 1,090,793 | $8,737 |
| Lynx1 Capital Management LP | 677,915 | $5,430 |
| Nantahala Capital Management, LLC | 600,000 | $4,806 |
| VANGUARD GROUP INC | 489,639 | $3,922 |
| BlackRock, Inc. | 457,399 | $3,664 |
| TCG Crossover Management, LLC | 416,301 | $3,335 |
| Siren, L.L.C. | 347,718 | $2,785 |
| JANE STREET GROUP, LLC | 288,457 | $2,311 |
| 72 Investment Holdings, LLC | 276,831 | $2,217 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 196,827 | $1,577 |
| GEODE CAPITAL MANAGEMENT, LLC | 162,760 | $1,304 |
| MILLENNIUM MANAGEMENT LLC | 161,092 | $1,290 |
| STATE STREET CORP | 146,221 | $1,171 |
| TWO SIGMA INVESTMENTS, LP | 78,984 | $633 |
| RENAISSANCE TECHNOLOGIES LLC | 74,900 | $600 |
| MORGAN STANLEY | 69,728 | $559 |
| EMERALD MUTUAL FUND ADVISERS TRUST | 65,548 | $525 |
| F/M Investments LLC | 65,548 | $525 |
| CITADEL ADVISORS LLC | 58,329 | $467 |
| XTX Topco Ltd | 57,067 | $457 |
| NORTHERN TRUST CORP | 55,640 | $446 |
| GOLDMAN SACHS GROUP INC | 51,950 | $416 |
| Graham Capital Management, L.P. | 40,766 | $327 |
| AQR CAPITAL MANAGEMENT LLC | 40,647 | $326 |
| FMR LLC | 37,857 | $303 |
| ACADIAN ASSET MANAGEMENT LLC | 33,790 | $0 |
| AIHC Capital Management Ltd | 30,265 | $242 |
| SIMPLEX TRADING, LLC | 28,247 | $226 |
| Quantinno Capital Management LP | 27,597 | $221 |
| ALGERT GLOBAL LLC | 27,065 | $0 |
| Quadrature Capital Ltd | 27,064 | $217 |
| Engineers Gate Manager LP | 26,885 | $215 |
| RAYMOND JAMES FINANCIAL INC | 23,031 | $184 |
| UBS Group AG | 19,995 | $160 |
| MARSHALL WACE, LLP | 19,772 | $158 |
| Bank of New York Mellon Corp | 18,855 | $151 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 16,329 | $131 |
| DEUTSCHE BANK AG\ | 12,758 | $102 |
| TWO SIGMA ADVISERS, LP | 11,237 | $90 |
| AMERICAN CENTURY COMPANIES INC | 10,590 | $85 |
| Jain Global LLC | 10,574 | $85 |
| GUGGENHEIM CAPITAL LLC | 10,439 | $84 |
| RHUMBLINE ADVISERS | 10,250 | $82 |
| AlphaQuest LLC | 7,703 | $62 |
| WELLS FARGO & COMPANY/MN | 7,522 | $60 |
| BANK OF AMERICA CORP /DE/ | 5,896 | $47 |
| GROUP ONE TRADING, L.P. | 4,000 | $32 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 3,146 | $25 |
| NEW YORK STATE COMMON RETIREMENT FUND | 3,000 | $24 |
| JPMORGAN CHASE & CO | 2,838 | $23 |
| Russell Investments Group, Ltd. | 1,930 | $15 |
| North Star Investment Management Corp. | 1,800 | $14 |
| Steward Partners Investment Advisory, LLC | 1,500 | $12 |
| BNP PARIBAS ARBITRAGE, SA | 1,487 | $12 |
| OSAIC HOLDINGS, INC. | 1,417 | $11 |
| Tower Research Capital LLC (TRC) | 1,391 | $11 |
| Police & Firemen's Retirement System of New Jersey | 1,373 | $11 |
| TD Waterhouse Canada Inc. | 800 | $6 |
| PNC Financial Services Group, Inc. | 740 | $6 |
| CITIGROUP INC | 607 | $5 |
| Ameritas Investment Partners, Inc. | 598 | $5 |
| Legal & General Group Plc | 526 | $4 |
| Sterling Capital Management LLC | 458 | $4 |
| DUNCKER STREETT & CO INC | 437 | $4 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 408 | $3 |
| FEDERATED HERMES, INC. | 302 | $2 |
| CWM, LLC | 288 | $0 |
| ROYAL BANK OF CANADA | 224 | $2 |
| AMALGAMATED BANK | 208 | $0 |
| Optiver Holding B.V. | 116 | $1 |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 110 | $4 |
| GAMMA Investing LLC | 102 | $1 |
| UBS ASSET MANAGEMENT AMERICAS INC | 91 | $1 |
| Keating Financial Advisory Services, Inc. | 63 | $1 |
| IFP Advisors, Inc | 40 | $0 |
| Global Retirement Partners, LLC | 35 | $0 |
| ROTHSCHILD INVESTMENT LLC | 6 | $0 |
| MAI Capital Management | 5 | $0 |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 2 | $0 |
| Allworth Financial LP | 1 | $0 |
| SBI Securities Co., Ltd. | 1 | $0 |
| Sunbelt Securities, Inc. | 1 | $0 |