KRYSTAL BIOTECH INC

Ticker: KRYS CUSIP: 501147102 Class: Common Stock

STATE STREET CORP's Holding History (CIK: 0000093751)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 1,342,303 Value ($000) $330,931 Avg Close $210.47 Range $175.85 - $265.92

Q3 2025

Shares 1,395,967 Value ($000) $246,430 Avg Close $149.68 Range $130.50 - $178.20

Q2 2025

Shares 1,355,346 Value ($000) $186,306 Avg Close $146.88 Range $122.80 - $182.16

Q1 2025

Shares 1,226,707 Value ($000) $221,175 Avg Close $168.21 Range $141.72 - $197.94

Q4 2024

Shares 1,278,975 Value ($000) $200,364 Avg Close $177.39 Range $154.16 - $207.84

Q3 2024

Shares 1,452,811 Value ($000) $264,455 Avg Close $192.81 Range $164.81 - $219.34

Q2 2024

Shares 1,332,875 Value ($000) $244,769 Avg Close $167.89 Range $144.00 - $191.78

Q1 2024

Shares 944,547 Value ($000) $168,063 Avg Close $138.91 Range $107.50 - $189.97

Q4 2023

Shares 1,237,497 Value ($000) $153,524 Avg Close $110.89 Range $93.95 - $129.85

Q3 2023

Shares 1,031,827 Value ($000) $119,692 Avg Close $122.00 Range $106.92 - $132.68

Q2 2023

Shares 903,691 Value ($000) $106,093 Avg Close $102.10 Range $77.09 - $131.80

Q1 2023

Shares 1,026,395 Value ($000) $82,173 Avg Close $78.56 Range $69.81 - $89.59

Q4 2022

Shares 1,038,983 Value ($000) $82,308 Avg Close $74.22 Range $61.11 - $81.97

Q3 2022

Shares 994,144 Value ($000) $69,292 Avg Close $72.25 Range $63.02 - $85.11

Q2 2022

Shares 1,036,041 Value ($000) $68,026 Avg Close $62.21 Range $47.67 - $74.53

Q1 2022

Shares 1,068,656 Value ($000) $71,108 Avg Close $62.42 Range $50.03 - $73.94

Q4 2021

Shares 701,801 Value ($000) $49,091 Avg Close $58.21 Range $38.86 - $102.99

Q3 2021

Shares 737,053 Value ($000) $38,482 Avg Close $59.20 Range $51.04 - $72.55

Q2 2021

Shares 712,997 Value ($000) $48,484 Avg Close $69.80 Range $59.29 - $83.00

Q1 2021

Shares 658,958 Value ($000) $50,766 Avg Close $72.70 Range $57.06 - $87.29

Q4 2020

Shares 560,250 Value ($000) $33,615 Avg Close $49.94 Range $40.04 - $62.95

Q3 2020

Shares 592,336 Value ($000) $25,500 Avg Close $43.43 Range $37.68 - $48.80

Q2 2020

Shares 694,825 Value ($000) $28,780 Avg Close $48.11 Range $35.33 - $61.86

Q1 2020

Shares 467,393 Value ($000) $20,210 Avg Close $52.30 Range $33.09 - $66.85

Q4 2019

Shares 456,225 Value ($000) $25,266 Avg Close $49.06 Range $31.89 - $66.50

Q3 2019

Shares 466,444 Value ($000) $16,197 Avg Close $44.70 Range $33.62 - $51.67

Q2 2019

Shares 158,146 Value ($000) $6,369 Avg Close $32.69 Range $22.02 - $46.90

Q1 2019

Shares 7,003 Value ($000) $230 Avg Close $23.57 Range $18.50 - $33.12

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	1,342,303	$330,931	$210.47	$175.85 - $265.92
Q3 2025	1,395,967	$246,430	$149.68	$130.50 - $178.20
Q2 2025	1,355,346	$186,306	$146.88	$122.80 - $182.16
Q1 2025	1,226,707	$221,175	$168.21	$141.72 - $197.94
Q4 2024	1,278,975	$200,364	$177.39	$154.16 - $207.84
Q3 2024	1,452,811	$264,455	$192.81	$164.81 - $219.34
Q2 2024	1,332,875	$244,769	$167.89	$144.00 - $191.78
Q1 2024	944,547	$168,063	$138.91	$107.50 - $189.97
Q4 2023	1,237,497	$153,524	$110.89	$93.95 - $129.85
Q3 2023	1,031,827	$119,692	$122.00	$106.92 - $132.68
Q2 2023	903,691	$106,093	$102.10	$77.09 - $131.80
Q1 2023	1,026,395	$82,173	$78.56	$69.81 - $89.59
Q4 2022	1,038,983	$82,308	$74.22	$61.11 - $81.97
Q3 2022	994,144	$69,292	$72.25	$63.02 - $85.11
Q2 2022	1,036,041	$68,026	$62.21	$47.67 - $74.53
Q1 2022	1,068,656	$71,108	$62.42	$50.03 - $73.94
Q4 2021	701,801	$49,091	$58.21	$38.86 - $102.99
Q3 2021	737,053	$38,482	$59.20	$51.04 - $72.55
Q2 2021	712,997	$48,484	$69.80	$59.29 - $83.00
Q1 2021	658,958	$50,766	$72.70	$57.06 - $87.29
Q4 2020	560,250	$33,615	$49.94	$40.04 - $62.95
Q3 2020	592,336	$25,500	$43.43	$37.68 - $48.80
Q2 2020	694,825	$28,780	$48.11	$35.33 - $61.86
Q1 2020	467,393	$20,210	$52.30	$33.09 - $66.85
Q4 2019	456,225	$25,266	$49.06	$31.89 - $66.50
Q3 2019	466,444	$16,197	$44.70	$33.62 - $51.67
Q2 2019	158,146	$6,369	$32.69	$22.02 - $46.90
Q1 2019	7,003	$230	$23.57	$18.50 - $33.12