| FMR LLC | 4,349,628 | $1,072,357 |
| BlackRock, Inc. | 3,937,817 | $970,829 |
| Avoro Capital Advisors LLC | 2,888,888 | $712,226 |
| VANGUARD GROUP INC | 2,778,845 | $685,096 |
| STATE STREET CORP | 1,342,303 | $330,931 |
| Soleus Capital Management, L.P. | 941,059 | $232,009 |
| Capital World Investors | 809,500 | $199,574 |
| Redmile Group, LLC | 677,705 | $167,081 |
| Hood River Capital Management LLC | 613,302 | $151,203 |
| GEODE CAPITAL MANAGEMENT, LLC | 611,878 | $150,878 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 529,955 | $131 |
| DIMENSIONAL FUND ADVISORS LP | 492,968 | $121,538 |
| Frazier Life Sciences Management, L.P. | 488,460 | $120,425 |
| Bellevue Group AG | 410,323 | $101,161 |
| CITADEL ADVISORS LLC | 386,505 | $95,289 |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 376,340 | $92,783 |
| GOLDMAN SACHS GROUP INC | 293,525 | $72,366 |
| NORGES BANK | 284,573 | $70,159 |
| NORTHERN TRUST CORP | 247,443 | $61,005 |
| FIRST TRUST ADVISORS LP | 245,276 | $60,470 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 242,774 | $59,854 |
| MORGAN STANLEY | 221,481 | $54,605 |
| JANUS HENDERSON GROUP PLC | 219,440 | $54,147 |
| BRAIDWELL LP | 202,101 | $49,826 |
| BANK OF AMERICA CORP /DE/ | 190,807 | $47,042 |
| Nuveen, LLC | 189,094 | $46,619 |
| MARSHALL WACE, LLP | 183,754 | $45,303 |
| PRINCIPAL FINANCIAL GROUP INC | 165,074 | $40,697 |
| UBS Group AG | 159,595 | $39,347 |
| Pictet Asset Management Holding SA | 156,568 | $38,600 |
| Bank of New York Mellon Corp | 151,313 | $37,305 |
| Woodline Partners LP | 150,616 | $37,133 |
| JPMORGAN CHASE & CO | 134,624 | $33,190 |
| FRANKLIN RESOURCES INC | 125,675 | $30,984 |
| ORBIMED ADVISORS LLC | 119,800 | $29,535 |
| Handelsbanken Fonder AB | 105,800 | $26 |
| Voya Investment Management LLC | 103,261 | $25,458 |
| TimesSquare Capital Management, LLC | 97,400 | $24,013 |
| S Squared Technology, LLC | 96,215 | $23,721 |
| Public Sector Pension Investment Board | 89,362 | $22,031 |
| C WorldWide Group Holding A/S | 85,809 | $21 |
| SEGALL BRYANT & HAMILL, LLC | 83,246 | $20,523 |
| RAYMOND JAMES FINANCIAL INC | 76,538 | $18,966 |
| Biondo Investment Advisors, LLC | 68,130 | $16,797 |
| RHUMBLINE ADVISERS | 66,436 | $16,379 |
| Legal & General Group Plc | 63,361 | $15,621 |
| ACT CAPITAL MANAGEMENT, LLC | 60,500 | $14,916 |
| BARCLAYS PLC | 60,062 | $14,808 |
| Invesco Ltd. | 60,008 | $14,794 |
| TD Asset Management Inc | 54,142 | $13,348 |
| BNP PARIBAS ARBITRAGE, SA | 53,911 | $13,291 |
| AMERIPRISE FINANCIAL INC | 52,345 | $12,905 |
| Skandinaviska Enskilda Banken AB (publ) | 46,732 | $11,521 |
| Swiss National Bank | 42,900 | $10,577 |
| Palisades Investment Partners, LLC | 42,765 | $10,543 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 40,629 | $10,056 |
| abrdn plc | 39,360 | $9,704 |
| Corient Private Wealth LLC | 38,290 | $9,502 |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | 37,269 | $9,188 |
| FEDERATED HERMES, INC. | 34,541 | $8,516 |
| HealthInvest Partners AB | 33,853 | $8,346 |
| UBS ASSET MANAGEMENT AMERICAS INC | 33,617 | $8,288 |
| SEI INVESTMENTS CO | 32,310 | $7,966 |
| WELLS FARGO & COMPANY/MN | 31,572 | $7,784 |
| ALLIANCEBERNSTEIN L.P. | 31,529 | $7,773 |
| NEW YORK STATE COMMON RETIREMENT FUND | 31,342 | $7,727 |
| CITIGROUP INC | 29,943 | $7,382 |
| CASTLEARK MANAGEMENT LLC | 29,260 | $7,214 |
| Russell Investments Group, Ltd. | 28,954 | $7,138 |
| PRUDENTIAL FINANCIAL INC | 27,015 | $6,660 |
| VICTORY CAPITAL MANAGEMENT INC | 26,461 | $6,524 |
| Granite Investment Partners, LLC | 25,760 | $6,351 |
| Rhenman & Partners Asset Management AB | 25,000 | $6,164 |
| EAM Investors, LLC | 24,667 | $6,081 |
| Rafferty Asset Management, LLC | 24,268 | $5,983 |
| EFG International AG | 23,569 | $5,817 |
| DEUTSCHE BANK AG\ | 22,450 | $5,535 |
| GREAT WEST LIFE ASSURANCE CO /CAN/ | 22,087 | $5 |
| Elmind Capital, LP | 22,000 | $5,424 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 20,583 | $5,075 |
| BESSEMER GROUP INC | 20,260 | $5 |
| ADAR1 Capital Management, LLC | 20,014 | $4,934 |
| GW&K Investment Management, LLC | 19,581 | $5 |
| SG Americas Securities, LLC | 18,909 | $5 |
| Fiera Capital Corp | 18,857 | $4,649 |
| State of Alaska, Department of Revenue | 17,902 | $4 |
| Thrivent Financial for Lutherans | 17,734 | $4 |
| 1832 Asset Management L.P. | 17,600 | $4,339 |
| PERCEPTIVE ADVISORS LLC | 17,500 | $4,314 |
| Decheng Capital LLC | 17,300 | $4,265 |
| Pinnacle Financial Partners, Inc. | 16,983 | $4,187 |
| Verition Fund Management LLC | 16,969 | $4,184 |
| Evolutionary Tree Capital Management, LLC | 16,811 | $4,145 |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 15,756 | $3,884 |
| NEW YORK STATE TEACHERS RETIREMENT SYSTEM | 15,650 | $4 |
| DekaBank Deutsche Girozentrale | 15,503 | $3 |
| Ikarian Capital, LLC | 14,814 | $3,652 |
| MILLENNIUM MANAGEMENT LLC | 14,658 | $3,614 |
| STATE OF WISCONSIN INVESTMENT BOARD | 14,466 | $3,566 |
| AQR CAPITAL MANAGEMENT LLC | 14,157 | $3,490 |
| 232 other institutions | 619,413 | $139,570 |