KRYSTAL BIOTECH INC

Ticker: KRYS CUSIP: 501147102 Class: Common Stock

STATE OF WISCONSIN INVESTMENT BOARD's Holding History (CIK: 0000854157)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 14,466 Value ($000) $3,566 Avg Close $210.47 Range $175.85 - $265.92

Q3 2025

Shares 29,340 Value ($000) $5,179 Avg Close $149.68 Range $130.50 - $178.20

Q2 2025

Shares 36,089 Value ($000) $4,961 Avg Close $146.88 Range $122.80 - $182.16

Q1 2025

Shares 24,183 Value ($000) $4,360 Avg Close $168.21 Range $141.72 - $197.94

Q4 2024

Shares 24,502 Value ($000) $3,838 Avg Close $177.39 Range $154.16 - $207.84

Q3 2024

Shares 23,068 Value ($000) $4,199 Avg Close $192.81 Range $164.81 - $219.34

Q2 2024

Shares 25,310 Value ($000) $4,648 Avg Close $167.89 Range $144.00 - $191.78

Q1 2024

Shares 16,215 Value ($000) $2,885 Avg Close $138.91 Range $107.50 - $189.97

Q4 2023

Shares 14,896 Value ($000) $1,848 Avg Close $110.89 Range $93.95 - $129.85

Q3 2023

Shares 20,627 Value ($000) $2,393 Avg Close $122.00 Range $106.92 - $132.68

Q2 2023

Shares 16,727 Value ($000) $1,964 Avg Close $102.10 Range $77.09 - $131.80

Q1 2023

Shares 16,571 Value ($000) $1,327 Avg Close $78.56 Range $69.81 - $89.59

Q4 2022

Shares 17,539 Value ($000) $1,389 Avg Close $74.22 Range $61.11 - $81.97

Q3 2022

Shares 17,747 Value ($000) $1,237 Avg Close $72.25 Range $63.02 - $85.11

Q2 2022

Shares 18,860 Value ($000) $1,238 Avg Close $62.21 Range $47.67 - $74.53

Q1 2022

Shares 23,400 Value ($000) $1,557 Avg Close $62.42 Range $50.03 - $73.94

Q4 2021

Shares 27,200 Value ($000) $1,903 Avg Close $58.21 Range $38.86 - $102.99

Q3 2021

Shares 23,400 Value ($000) $1,222 Avg Close $59.20 Range $51.04 - $72.55

Q2 2021

Shares 18,900 Value ($000) $1,285 Avg Close $69.80 Range $59.29 - $83.00

Q1 2021

Shares 18,900 Value ($000) $1,456 Avg Close $72.70 Range $57.06 - $87.29

Q4 2020

Shares 18,900 Value ($000) $1,134 Avg Close $49.94 Range $40.04 - $62.95

Q3 2020

Shares 19,100 Value ($000) $822 Avg Close $43.43 Range $37.68 - $48.80

Q2 2020

Shares 16,200 Value ($000) $671 Avg Close $48.11 Range $35.33 - $61.86

Q1 2020

Shares 16,200 Value ($000) $700 Avg Close $52.30 Range $33.09 - $66.85

Q4 2019

Shares 13,100 Value ($000) $725 Avg Close $49.06 Range $31.89 - $66.50

Q3 2019

Shares 13,100 Value ($000) $455 Avg Close $44.70 Range $33.62 - $51.67

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	14,466	$3,566	$210.47	$175.85 - $265.92
Q3 2025	29,340	$5,179	$149.68	$130.50 - $178.20
Q2 2025	36,089	$4,961	$146.88	$122.80 - $182.16
Q1 2025	24,183	$4,360	$168.21	$141.72 - $197.94
Q4 2024	24,502	$3,838	$177.39	$154.16 - $207.84
Q3 2024	23,068	$4,199	$192.81	$164.81 - $219.34
Q2 2024	25,310	$4,648	$167.89	$144.00 - $191.78
Q1 2024	16,215	$2,885	$138.91	$107.50 - $189.97
Q4 2023	14,896	$1,848	$110.89	$93.95 - $129.85
Q3 2023	20,627	$2,393	$122.00	$106.92 - $132.68
Q2 2023	16,727	$1,964	$102.10	$77.09 - $131.80
Q1 2023	16,571	$1,327	$78.56	$69.81 - $89.59
Q4 2022	17,539	$1,389	$74.22	$61.11 - $81.97
Q3 2022	17,747	$1,237	$72.25	$63.02 - $85.11
Q2 2022	18,860	$1,238	$62.21	$47.67 - $74.53
Q1 2022	23,400	$1,557	$62.42	$50.03 - $73.94
Q4 2021	27,200	$1,903	$58.21	$38.86 - $102.99
Q3 2021	23,400	$1,222	$59.20	$51.04 - $72.55
Q2 2021	18,900	$1,285	$69.80	$59.29 - $83.00
Q1 2021	18,900	$1,456	$72.70	$57.06 - $87.29
Q4 2020	18,900	$1,134	$49.94	$40.04 - $62.95
Q3 2020	19,100	$822	$43.43	$37.68 - $48.80
Q2 2020	16,200	$671	$48.11	$35.33 - $61.86
Q1 2020	16,200	$700	$52.30	$33.09 - $66.85
Q4 2019	13,100	$725	$49.06	$31.89 - $66.50
Q3 2019	13,100	$455	$44.70	$33.62 - $51.67