KRYSTAL BIOTECH INC

Ticker: KRYS CUSIP: 501147102 Class: Common Stock

MANUFACTURERS LIFE INSURANCE COMPANY, THE's Holding History (CIK: 0000928047)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 40,629 Value ($000) $10,056 Avg Close $210.47 Range $175.85 - $265.92

Q3 2025

Shares 34,455 Value ($000) $6,082 Avg Close $149.68 Range $130.50 - $178.20

Q2 2025

Shares 24,680 Value ($000) $3,393 Avg Close $146.88 Range $122.80 - $182.16

Q1 2025

Shares 32,366 Value ($000) $5,836 Avg Close $168.21 Range $141.72 - $197.94

Q4 2024

Shares 35,206 Value ($000) $5,515 Avg Close $177.39 Range $154.16 - $207.84

Q3 2024

Shares 31,225 Value ($000) $5,684 Avg Close $192.81 Range $164.81 - $219.34

Q2 2024

Shares 41,015 Value ($000) $7,532 Avg Close $167.89 Range $144.00 - $191.78

Q1 2024

Shares 41,298 Value ($000) $7,348 Avg Close $138.91 Range $107.50 - $189.97

Q4 2023

Shares 29,250 Value ($000) $3,629 Avg Close $110.89 Range $93.95 - $129.85

Q3 2023

Shares 20,437 Value ($000) $2,371 Avg Close $122.00 Range $106.92 - $132.68

Q2 2023

Shares 21,629 Value ($000) $2,539 Avg Close $102.10 Range $77.09 - $131.80

Q1 2023

Shares 8,521 Value ($000) $682 Avg Close $78.56 Range $69.81 - $89.59

Q4 2022

Shares 8,485 Value ($000) $672 Avg Close $74.22 Range $61.11 - $81.97

Q3 2022

Shares 8,335 Value ($000) $581 Avg Close $72.25 Range $63.02 - $85.11

Q2 2022

Shares 8,522 Value ($000) $560 Avg Close $62.21 Range $47.67 - $74.53

Q1 2022

Shares 8,126 Value ($000) $541 Avg Close $62.42 Range $50.03 - $73.94

Q4 2021

Shares 9,327 Value ($000) $652 Avg Close $58.21 Range $38.86 - $102.99

Q3 2021

Shares 9,537 Value ($000) $498 Avg Close $59.20 Range $51.04 - $72.55

Q2 2021

Shares 10,312 Value ($000) $701 Avg Close $69.80 Range $59.29 - $83.00

Q1 2021

Shares 8,717 Value ($000) $672 Avg Close $72.70 Range $57.06 - $87.29

Q4 2020

Shares 8,387 Value ($000) $503 Avg Close $49.94 Range $40.04 - $62.95

Q3 2020

Shares 7,783 Value ($000) $335 Avg Close $43.43 Range $37.68 - $48.80

Q2 2020

Shares 7,318 Value ($000) $302 Avg Close $48.11 Range $35.33 - $61.86

Q1 2020

Shares 6,869 Value ($000) $297 Avg Close $52.30 Range $33.09 - $66.85

Q4 2019

Shares 6,454 Value ($000) $357 Avg Close $49.06 Range $31.89 - $66.50

Q3 2019

Shares 6,371 Value ($000) $226 Avg Close $44.70 Range $33.62 - $51.67

Q2 2019

Shares 5,681 Value ($000) $229 Avg Close $32.69 Range $22.02 - $46.90

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	40,629	$10,056	$210.47	$175.85 - $265.92
Q3 2025	34,455	$6,082	$149.68	$130.50 - $178.20
Q2 2025	24,680	$3,393	$146.88	$122.80 - $182.16
Q1 2025	32,366	$5,836	$168.21	$141.72 - $197.94
Q4 2024	35,206	$5,515	$177.39	$154.16 - $207.84
Q3 2024	31,225	$5,684	$192.81	$164.81 - $219.34
Q2 2024	41,015	$7,532	$167.89	$144.00 - $191.78
Q1 2024	41,298	$7,348	$138.91	$107.50 - $189.97
Q4 2023	29,250	$3,629	$110.89	$93.95 - $129.85
Q3 2023	20,437	$2,371	$122.00	$106.92 - $132.68
Q2 2023	21,629	$2,539	$102.10	$77.09 - $131.80
Q1 2023	8,521	$682	$78.56	$69.81 - $89.59
Q4 2022	8,485	$672	$74.22	$61.11 - $81.97
Q3 2022	8,335	$581	$72.25	$63.02 - $85.11
Q2 2022	8,522	$560	$62.21	$47.67 - $74.53
Q1 2022	8,126	$541	$62.42	$50.03 - $73.94
Q4 2021	9,327	$652	$58.21	$38.86 - $102.99
Q3 2021	9,537	$498	$59.20	$51.04 - $72.55
Q2 2021	10,312	$701	$69.80	$59.29 - $83.00
Q1 2021	8,717	$672	$72.70	$57.06 - $87.29
Q4 2020	8,387	$503	$49.94	$40.04 - $62.95
Q3 2020	7,783	$335	$43.43	$37.68 - $48.80
Q2 2020	7,318	$302	$48.11	$35.33 - $61.86
Q1 2020	6,869	$297	$52.30	$33.09 - $66.85
Q4 2019	6,454	$357	$49.06	$31.89 - $66.50
Q3 2019	6,371	$226	$44.70	$33.62 - $51.67
Q2 2019	5,681	$229	$32.69	$22.02 - $46.90