KRYSTAL BIOTECH INC

Ticker: KRYS CUSIP: 501147102 Class: Common Stock

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q3 2021

Shares 10,683 Value ($000) $558 Avg Close $59.20 Range $51.04 - $72.55

Q2 2020

Shares 6,653 Value ($000) $276 Avg Close $48.11 Range $35.33 - $61.86

Period	Shares	Value ($000)	Average Close	Price Range
Q3 2021	10,683	$558	$59.20	$51.04 - $72.55
Q2 2020	6,653	$276	$48.11	$35.33 - $61.86