KRYSTAL BIOTECH INC

Ticker: KRYS CUSIP: 501147102 Class: Common Stock

Swiss National Bank's Holding History (CIK: 0001582202)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 42,900 Value ($000) $10,577 Avg Close $210.47 Range $175.85 - $265.92

Q3 2025

Shares 42,000 Value ($000) $7,414 Avg Close $149.68 Range $130.50 - $178.20

Q2 2025

Shares 41,400 Value ($000) $5,691 Avg Close $146.88 Range $122.80 - $182.16

Q1 2025

Shares 41,800 Value ($000) $7,537 Avg Close $168.21 Range $141.72 - $197.94

Q4 2024

Shares 42,400 Value ($000) $6,642 Avg Close $177.39 Range $154.16 - $207.84

Q3 2024

Shares 39,100 Value ($000) $7,117 Avg Close $192.81 Range $164.81 - $219.34

Q2 2024

Shares 36,200 Value ($000) $6,648 Avg Close $167.89 Range $144.00 - $191.78

Q1 2024

Shares 36,200 Value ($000) $6,441 Avg Close $138.91 Range $107.50 - $189.97

Q4 2023

Shares 35,900 Value ($000) $4,454 Avg Close $110.89 Range $93.95 - $129.85

Q3 2023

Shares 39,400 Value ($000) $4,570 Avg Close $122.00 Range $106.92 - $132.68

Q2 2023

Shares 42,100 Value ($000) $4,943 Avg Close $102.10 Range $77.09 - $131.80

Q1 2023

Shares 38,900 Value ($000) $3,114 Avg Close $78.56 Range $69.81 - $89.59

Q4 2022

Shares 43,400 Value ($000) $3,438 Avg Close $74.22 Range $61.11 - $81.97

Q3 2022

Shares 42,600 Value ($000) $2,969 Avg Close $72.25 Range $63.02 - $85.11

Q2 2022

Shares 41,200 Value ($000) $2,705 Avg Close $62.21 Range $47.67 - $74.53

Q1 2022

Shares 41,200 Value ($000) $2,741 Avg Close $62.42 Range $50.03 - $73.94

Q4 2021

Shares 38,400 Value ($000) $2,686 Avg Close $58.21 Range $38.86 - $102.99

Q3 2021

Shares 31,800 Value ($000) $1,660 Avg Close $59.20 Range $51.04 - $72.55

Q2 2021

Shares 31,400 Value ($000) $2,135 Avg Close $69.80 Range $59.29 - $83.00

Q1 2021

Shares 29,300 Value ($000) $2,257 Avg Close $72.70 Range $57.06 - $87.29

Q4 2020

Shares 28,900 Value ($000) $1,734 Avg Close $49.94 Range $40.04 - $62.95

Q3 2020

Shares 28,900 Value ($000) $1,244 Avg Close $43.43 Range $37.68 - $48.80

Q2 2020

Shares 28,400 Value ($000) $1,176 Avg Close $48.11 Range $35.33 - $61.86

Q1 2020

Shares 21,800 Value ($000) $943 Avg Close $52.30 Range $33.09 - $66.85

Q4 2019

Shares 21,500 Value ($000) $1,191 Avg Close $49.06 Range $31.89 - $66.50

Q3 2019

Shares 20,500 Value ($000) $712 Avg Close $44.70 Range $33.62 - $51.67

Q2 2019

Shares 20,500 Value ($000) $826 Avg Close $32.69 Range $22.02 - $46.90

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	42,900	$10,577	$210.47	$175.85 - $265.92
Q3 2025	42,000	$7,414	$149.68	$130.50 - $178.20
Q2 2025	41,400	$5,691	$146.88	$122.80 - $182.16
Q1 2025	41,800	$7,537	$168.21	$141.72 - $197.94
Q4 2024	42,400	$6,642	$177.39	$154.16 - $207.84
Q3 2024	39,100	$7,117	$192.81	$164.81 - $219.34
Q2 2024	36,200	$6,648	$167.89	$144.00 - $191.78
Q1 2024	36,200	$6,441	$138.91	$107.50 - $189.97
Q4 2023	35,900	$4,454	$110.89	$93.95 - $129.85
Q3 2023	39,400	$4,570	$122.00	$106.92 - $132.68
Q2 2023	42,100	$4,943	$102.10	$77.09 - $131.80
Q1 2023	38,900	$3,114	$78.56	$69.81 - $89.59
Q4 2022	43,400	$3,438	$74.22	$61.11 - $81.97
Q3 2022	42,600	$2,969	$72.25	$63.02 - $85.11
Q2 2022	41,200	$2,705	$62.21	$47.67 - $74.53
Q1 2022	41,200	$2,741	$62.42	$50.03 - $73.94
Q4 2021	38,400	$2,686	$58.21	$38.86 - $102.99
Q3 2021	31,800	$1,660	$59.20	$51.04 - $72.55
Q2 2021	31,400	$2,135	$69.80	$59.29 - $83.00
Q1 2021	29,300	$2,257	$72.70	$57.06 - $87.29
Q4 2020	28,900	$1,734	$49.94	$40.04 - $62.95
Q3 2020	28,900	$1,244	$43.43	$37.68 - $48.80
Q2 2020	28,400	$1,176	$48.11	$35.33 - $61.86
Q1 2020	21,800	$943	$52.30	$33.09 - $66.85
Q4 2019	21,500	$1,191	$49.06	$31.89 - $66.50
Q3 2019	20,500	$712	$44.70	$33.62 - $51.67
Q2 2019	20,500	$826	$32.69	$22.02 - $46.90