KYTHERA BIOPHARMACEUTICALS I

CUSIP: 501570105 Class: COM

RENAISSANCE TECHNOLOGIES LLC's Holding History (CIK: 0001037389)

Note: Option positions (PUT/CALL) are excluded.

Q1 2014
Shares 116,400 Value ($000) $4,628 Avg Close — Range —
Q4 2013
Shares 41,200 Value ($000) $1,539 Avg Close — Range —