KYTHERA BIOPHARMACEUTICALS I

CUSIP: 501570105 Class: COM

ORBIMED ADVISORS LLC's Holding History (CIK: 0001055951)

Note: Option positions (PUT/CALL) are excluded.

Q1 2015
Shares 947,900 Value ($000) $47,537 Avg Close — Range —
Q4 2014
Shares 722,900 Value ($000) $25,070 Avg Close — Range —