| Deep Track Capital, LP | 3,352,804 | $74,633 |
| BlackRock, Inc. | 2,238,934 | $49,839 |
| RA CAPITAL MANAGEMENT, L.P. | 2,208,604 | $49,164 |
| TCG Crossover Management, LLC | 1,745,015 | $38,844 |
| JPMORGAN CHASE & CO | 1,611,482 | $35,872 |
| Commodore Capital LP | 1,500,000 | $33,390 |
| Trails Edge Capital Partners, LP | 1,395,608 | $31,066 |
| Logos Global Management LP | 1,200,000 | $26,712 |
| VANGUARD GROUP INC | 1,112,978 | $24,775 |
| Spruce Street Capital LP | 1,005,593 | $22,385 |
| BALYASNY ASSET MANAGEMENT L.P. | 896,806 | $19,963 |
| JENNISON ASSOCIATES LLC | 821,852 | $18,294 |
| Vivo Capital, LLC | 800,000 | $17,808 |
| Alyeska Investment Group, L.P. | 675,000 | $15,026 |
| Nantahala Capital Management, LLC | 675,000 | $15,026 |
| GEODE CAPITAL MANAGEMENT, LLC | 441,454 | $9,830 |
| CITADEL ADVISORS LLC | 407,668 | $9,075 |
| GOLDMAN SACHS GROUP INC | 303,115 | $6,747 |
| Nan Fung Group Holdings Ltd | 300,000 | $6,678 |
| STATE STREET CORP | 250,030 | $5,566 |
| FMR LLC | 221,865 | $4,939 |
| BAKER BROS. ADVISORS LP | 200,000 | $4,452 |
| AMERIPRISE FINANCIAL INC | 193,544 | $4,308 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 177,616 | $3,954 |
| NORTHERN TRUST CORP | 143,966 | $3,205 |
| HighVista Strategies LLC | 140,107 | $3,119 |
| Integral Health Asset Management, LLC | 100,000 | $2,226 |
| Longbow Finance SA | 82,336 | $1,833 |
| Boxer Capital Management, LLC | 70,000 | $1,558 |
| UBS Group AG | 50,713 | $1,129 |
| BANK OF AMERICA CORP /DE/ | 43,758 | $974 |
| Bank of New York Mellon Corp | 40,517 | $902 |
| JANE STREET GROUP, LLC | 31,733 | $706 |
| BARCLAYS PLC | 30,215 | $673 |
| ACUTA CAPITAL PARTNERS, LLC | 30,000 | $668 |
| MORGAN STANLEY | 24,641 | $549 |
| Nuveen, LLC | 22,966 | $511 |
| WELLS FARGO & COMPANY/MN | 22,303 | $496 |
| Focus Partners Wealth | 20,095 | $447 |
| NORGES BANK | 20,000 | $445 |
| XTX Topco Ltd | 19,121 | $426 |
| MARSHALL WACE, LLP | 18,014 | $401 |
| RHUMBLINE ADVISERS | 16,283 | $362 |
| DEUTSCHE BANK AG\ | 13,298 | $296 |
| TWO SIGMA INVESTMENTS, LP | 12,720 | $283 |
| Jefferies Financial Group Inc. | 12,445 | $277 |
| MetLife Investment Management, LLC | 11,104 | $247 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 11,074 | $0 |
| Invesco Ltd. | 10,955 | $244 |
| Soleus Capital Management, L.P. | 10,000 | $223 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 8,966 | $200 |
| SG Americas Securities, LLC | 6,434 | $0 |
| FEDERATED HERMES, INC. | 5,000 | $111 |
| Police & Firemen's Retirement System of New Jersey | 4,425 | $99 |
| Persistent Asset Partners Ltd | 4,080 | $91 |
| BNP PARIBAS ARBITRAGE, SA | 4,007 | $89 |
| STRS OHIO | 3,400 | $76 |
| Legal & General Group Plc | 1,878 | $42 |
| Ameritas Investment Partners, Inc. | 1,562 | $35 |
| Russell Investments Group, Ltd. | 1,525 | $34 |
| Tower Research Capital LLC (TRC) | 1,361 | $30 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 1,184 | $26 |
| ROYAL BANK OF CANADA | 767 | $17 |
| AMALGAMATED BANK | 605 | $0 |
| Sterling Capital Management LLC | 592 | $13 |
| CITIGROUP INC | 435 | $10 |
| GAMMA Investing LLC | 14 | $0 |
| CWM, LLC | 8 | $0 |