LEAP THERAPEUTICS INC

Ticker: CYPH CUSIP: 52187K200 Class: COM NEW

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 72,172 Value ($000) $84 Avg Close $1.09 Range $0.39 - $3.70

Q3 2025

Shares 70,849 Value ($000) $32 Avg Close $0.32 Range $0.23 - $0.46

Q2 2025

Shares 13,897 Value ($000) $4 Avg Close $0.36 Range $0.22 - $0.46

Q1 2025

Shares 12,838 Value ($000) $4 Avg Close $1.10 Range $0.28 - $3.58

Q2 2024

Shares 23,324 Value ($000) $46 Avg Close $2.62 Range $1.69 - $4.39

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	72,172	$84	$1.09	$0.39 - $3.70
Q3 2025	70,849	$32	$0.32	$0.23 - $0.46
Q2 2025	13,897	$4	$0.36	$0.22 - $0.46
Q1 2025	12,838	$4	$1.10	$0.28 - $3.58
Q2 2024	23,324	$46	$2.62	$1.69 - $4.39