| FMR LLC | 24,268,223 | $527,591 |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 6,608,629 | $143,672 |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 6,164,677 | $134,020 |
| HHLR ADVISORS, LTD. | 5,984,550 | $130,104 |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 5,932,000 | $128,962 |
| BlackRock, Inc. | 4,276,913 | $92,980 |
| Point72 Asset Management, L.P. | 2,784,806 | $60,542 |
| Artisan Partners Limited Partnership | 2,341,074 | $50,895 |
| GOLDMAN SACHS GROUP INC | 2,174,535 | $47,274 |
| ALLIANCEBERNSTEIN L.P. | 1,517,067 | $32,981 |
| STATE STREET CORP | 1,516,368 | $32,966 |
| BRAIDWELL LP | 1,298,142 | $28,222 |
| Davern Capital Partners, LP | 1,056,668 | $22,972 |
| MATTHEWS INTERNATIONAL CAPITAL MANAGEMENT LLC | 956,824 | $20,801 |
| JPMORGAN CHASE & CO | 945,694 | $20,559 |
| Capital International Investors | 941,600 | $20,470 |
| JOHNSON & JOHNSON | 814,586 | $17,709 |
| IvyRock Asset Management (HK) Ltd | 804,000 | $17,479 |
| MARSHALL WACE, LLP | 755,953 | $16,434 |
| ArrowMark Colorado Holdings LLC | 721,790 | $15,692 |
| TWO SIGMA ADVISERS, LP | 689,600 | $14,992 |
| ACADIAN ASSET MANAGEMENT LLC | 582,154 | $13 |
| Hudson Bay Capital Management LP | 575,000 | $12,501 |
| GEODE CAPITAL MANAGEMENT, LLC | 555,436 | $11,980 |
| TWO SIGMA INVESTMENTS, LP | 526,070 | $11,437 |
| Jump Financial, LLC | 523,632 | $11,384 |
| MORGAN STANLEY | 482,550 | $10,491 |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 480,143 | $10,438 |
| Squarepoint Ops LLC | 409,974 | $8,913 |
| Eagle Health Investments LP | 408,652 | $8,884 |
| RENAISSANCE TECHNOLOGIES LLC | 402,800 | $8,757 |
| SG Americas Securities, LLC | 371,728 | $8 |
| BALYASNY ASSET MANAGEMENT L.P. | 343,785 | $7,474 |
| Empire Life Investments Inc. | 322,936 | $7,021 |
| Walleye Capital LLC | 299,463 | $6,510 |
| BANK OF AMERICA CORP /DE/ | 287,529 | $6,251 |
| NORTHERN TRUST CORP | 276,119 | $6,003 |
| BARCLAYS PLC | 273,820 | $5,953 |
| HSBC HOLDINGS PLC | 266,134 | $5,788 |
| BNP PARIBAS ARBITRAGE, SA | 264,923 | $5,759 |
| Candriam S.C.A. | 261,815 | $5,692 |
| Triata Capital Ltd | 252,600 | $5,492 |
| JANE STREET GROUP, LLC | 238,123 | $5,177 |
| Legal & General Group Plc | 226,950 | $4,934 |
| Ikarian Capital, LLC | 226,888 | $4,933 |
| UBS Group AG | 224,612 | $4,883 |
| Casdin Capital, LLC | 215,000 | $4,674 |
| CenterBook Partners LP | 213,024 | $4,631 |
| Woodline Partners LP | 205,077 | $4,458 |
| CITADEL ADVISORS LLC | 178,040 | $3,871 |
| Russell Investments Group, Ltd. | 175,833 | $3,786 |
| Sumitomo Mitsui Trust Holdings, Inc. | 166,590 | $3,622 |
| NEW YORK STATE COMMON RETIREMENT FUND | 163,148 | $3,547 |
| Swiss National Bank | 161,294 | $3,507 |
| DEUTSCHE BANK AG\ | 157,034 | $3,414 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 153,275 | $3,332 |
| iA Global Asset Management Inc. | 153,242 | $3 |
| VANGUARD GROUP INC | 149,619 | $3,253 |
| PANAGORA ASSET MANAGEMENT INC | 139,893 | $3,041 |
| Evergreen Quality Fund GP, Ltd. | 122,100 | $2,654 |
| Pictet Asset Management Holding SA | 111,465 | $2,423 |
| Engineers Gate Manager LP | 106,140 | $2,307 |
| Bank of New York Mellon Corp | 103,375 | $2,247 |
| SEI INVESTMENTS CO | 103,022 | $2,240 |
| Raiffeisen Bank International AG | 100,000 | $2,153 |
| Nuveen, LLC | 94,586 | $2,056 |
| NEOS Investment Management LLC | 92,017 | $2,000 |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 91,725 | $1,994 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 84,981 | $1,847 |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | 80,363 | $1,747 |
| ROYAL LONDON ASSET MANAGEMENT LTD | 79,400 | $1,726 |
| MILLENNIUM MANAGEMENT LLC | 77,194 | $1,678 |
| Mitsubishi UFJ Kokusai Asset Management Co., Ltd. | 75,078 | $1,615 |
| AMERIPRISE FINANCIAL INC | 75,062 | $1,632 |
| CITIGROUP INC | 74,997 | $1,630 |
| NORDEA INVESTMENT MANAGEMENT AB | 73,561 | $1,601 |
| STEMPOINT CAPITAL LP | 73,328 | $1,594 |
| Campbell & CO Investment Adviser LLC | 70,598 | $1,535 |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 66,955 | $1,442 |
| BOOTHBAY FUND MANAGEMENT, LLC | 65,826 | $1,431 |
| Bellevue Group AG | 63,971 | $1,391 |
| Man Group plc | 61,704 | $1,341 |
| Verition Fund Management LLC | 54,274 | $1,180 |
| TUDOR INVESTMENT CORP ET AL | 53,300 | $1,159 |
| Polar Capital Holdings Plc | 52,893 | $1,150 |
| AVIVA PLC | 52,744 | $1,147 |
| ABS Direct Equity Fund LLC | 47,200 | $1,026 |
| Qube Research & Technologies Ltd | 44,369 | $965 |
| GUGGENHEIM CAPITAL LLC | 44,107 | $959 |
| Handelsbanken Fonder AB | 42,000 | $1 |
| GROUP ONE TRADING, L.P. | 39,976 | $869 |
| Advisors Preferred, LLC | 37,584 | $808 |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 35,841 | $779 |
| LMR Partners LLP | 35,000 | $761 |
| Headlands Technologies LLC | 34,742 | $755 |
| Sterling Capital Management LLC | 34,275 | $745 |
| Rock Springs Capital Management LP | 33,800 | $735 |
| CAISSE DE DEPOT ET PLACEMENT DU QUEBEC | 30,778 | $669 |
| Virtus Investment Advisers, LLC | 30,617 | $666 |
| NOMURA HOLDINGS INC | 30,429 | $662 |
| 97 other institutions | 1,030,110 | $18,936 |