LION BIOTECHNOLOGIES INC

CUSIP: 53619R102 Class: COM

Opaleye Management Inc.'s Holding History (CIK: 0001595855)

Note: Option positions (PUT/CALL) are excluded.

Q1 2017

Shares 230,000 Value ($000) $1,713 Avg Close — Range —

Q4 2016

Shares 300,000 Value ($000) $2,085 Avg Close — Range —

Q3 2016

Shares 280,000 Value ($000) $2,304 Avg Close — Range —

Q2 2016

Shares 260,000 Value ($000) $2,106 Avg Close — Range —

Q1 2015

Shares 200,000 Value ($000) $2,422 Avg Close — Range —

Period	Shares	Value ($000)	Average Close	Price Range
Q1 2017	230,000	$1,713	—	—
Q4 2016	300,000	$2,085	—	—
Q3 2016	280,000	$2,304	—	—
Q2 2016	260,000	$2,106	—	—
Q1 2015	200,000	$2,422	—	—