| FARALLON CAPITAL MANAGEMENT LLC | 8,656,038 | $298,547 |
| Caligan Partners LP | 8,118,892 | $280,021 |
| BlackRock, Inc. | 5,488,363 | $189,294 |
| VANGUARD GROUP INC | 4,013,888 | $138,439 |
| FINDELL CAPITAL MANAGEMENT LLC | 2,851,449 | $98,346 |
| Opaleye Management Inc. | 2,435,000 | $84,982 |
| BANK OF AMERICA CORP /DE/ | 1,927,420 | $66,477 |
| STATE STREET CORP | 1,808,859 | $62,388 |
| Caprock Group, LLC | 1,783,921 | $61,527 |
| TCG Crossover Management, LLC | 1,710,084 | $58,981 |
| D. E. Shaw & Co., Inc. | 1,667,382 | $57,508 |
| GEODE CAPITAL MANAGEMENT, LLC | 1,620,811 | $55,911 |
| MPM BioImpact LLC | 1,400,869 | $48,316 |
| CITADEL ADVISORS LLC | 800,196 | $27,599 |
| GOLDMAN SACHS GROUP INC | 704,097 | $24,284 |
| Buckley Capital Advisors, LLC | 649,386 | $22,397 |
| BOOTHBAY FUND MANAGEMENT, LLC | 613,548 | $21,161 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 561,745 | $19,375 |
| NORTHERN TRUST CORP | 560,829 | $19,343 |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 532,425 | $18,363 |
| Eversept Partners, LP | 509,443 | $17,571 |
| FEDERATED HERMES, INC. | 486,333 | $16,774 |
| MORGAN STANLEY | 473,532 | $16,332 |
| PRUDENTIAL FINANCIAL INC | 459,766 | $15,857 |
| Invesco Ltd. | 420,621 | $14,507 |
| JANE STREET GROUP, LLC | 417,638 | $14,404 |
| Pale Fire Capital SE | 379,392 | $13,085 |
| FMR LLC | 378,344 | $13,049 |
| APIS CAPITAL ADVISORS, LLC | 355,200 | $12,251 |
| TWO SIGMA INVESTMENTS, LP | 350,048 | $12,073 |
| OBERWEIS ASSET MANAGEMENT INC/ | 329,200 | $11,354 |
| FIRST TRUST ADVISORS LP | 306,957 | $10,587 |
| Trexquant Investment LP | 279,138 | $9,627 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 262,106 | $9,040 |
| MIRABELLA FINANCIAL SERVICES LLP | 247,799 | $8,547 |
| WELLINGTON MANAGEMENT GROUP LLP | 233,144 | $8,041 |
| Patient Square Capital LP | 227,000 | $7,829 |
| RENAISSANCE TECHNOLOGIES LLC | 206,853 | $7,134 |
| Bank of New York Mellon Corp | 198,693 | $6,853 |
| DEUTSCHE BANK AG\ | 187,814 | $6,478 |
| T3 Companies, LLC | 176,401 | $6,084 |
| HRT FINANCIAL LP | 168,176 | $6 |
| Caption Management, LLC | 162,538 | $5,606 |
| Whitefort Capital Management, LP | 158,000 | $5,449 |
| BANCO BILBAO VIZCAYA ARGENTARIA, S.A. | 157,241 | $5,382 |
| HighVista Strategies LLC | 156,003 | $5,381 |
| Walleye Capital LLC | 155,349 | $5,358 |
| CAXTON ASSOCIATES LLP | 155,006 | $5,346 |
| Nuveen, LLC | 151,163 | $5,214 |
| UBS ASSET MANAGEMENT AMERICAS INC | 147,256 | $5,079 |
| CITIGROUP INC | 146,569 | $5,055 |
| MARSHALL WACE, LLP | 145,639 | $5,023 |
| Insight Wealth Strategies, LLC | 141,818 | $4,891 |
| BARCLAYS PLC | 131,814 | $4,546 |
| Greenland Capital Management LP | 131,500 | $4,535 |
| CenterBook Partners LP | 124,982 | $4,311 |
| JPMORGAN CHASE & CO | 121,661 | $4,196 |
| TWO SIGMA ADVISERS, LP | 121,400 | $4,187 |
| Swiss National Bank | 118,800 | $4,097 |
| Y-Intercept (Hong Kong) Ltd | 116,924 | $4,033 |
| ALGERT GLOBAL LLC | 112,380 | $4 |
| UBS Group AG | 111,762 | $3,855 |
| MILLENNIUM MANAGEMENT LLC | 105,616 | $3,643 |
| Engineers Gate Manager LP | 101,848 | $3,513 |
| Woodline Partners LP | 100,160 | $3,455 |
| JW Asset Management, LLC | 99,776 | $3,441 |
| AWH Capital, L.P. | 92,500 | $3,190 |
| Diametric Capital, LP | 91,489 | $3,155 |
| Seven Fleet Capital Management LP | 91,267 | $3,148 |
| Exome Asset Management LLC | 91,148 | $3,144 |
| OCCUDO QUANTITATIVE STRATEGIES LP | 90,086 | $3,107 |
| Elmind Capital, LP | 90,000 | $3,104 |
| Legal & General Group Plc | 85,646 | $2,954 |
| RAYMOND JAMES FINANCIAL INC | 84,426 | $2,912 |
| AMERIPRISE FINANCIAL INC | 81,251 | $2,802 |
| RHUMBLINE ADVISERS | 78,489 | $2,707 |
| OSAIC HOLDINGS, INC. | 77,384 | $2,669 |
| Verition Fund Management LLC | 75,000 | $2,587 |
| WELLS FARGO & COMPANY/MN | 74,970 | $2,586 |
| Russell Investments Group, Ltd. | 74,778 | $2,579 |
| Advisory Services Network, LLC | 72,665 | $2,506 |
| ALLIANCEBERNSTEIN L.P. | 68,650 | $2,368 |
| Squarepoint Ops LLC | 67,894 | $2,342 |
| Schonfeld Strategic Advisors LLC | 65,702 | $2,266 |
| GSA CAPITAL PARTNERS LLP | 63,176 | $2 |
| Sigma Planning Corp | 63,030 | $2,174 |
| STATE OF WISCONSIN INVESTMENT BOARD | 62,195 | $2,145 |
| Focus Partners Wealth | 61,156 | $1,639 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 57,953 | $1,999 |
| DV Trading LLC | 57,928 | $1,998 |
| BALYASNY ASSET MANAGEMENT L.P. | 57,670 | $1,989 |
| TUDOR INVESTMENT CORP ET AL | 56,741 | $1,957 |
| SG Americas Securities, LLC | 54,696 | $2 |
| WCG Wealth Advisors LLC | 54,411 | $1,877 |
| Mariner, LLC | 49,752 | $1,716 |
| SAPIENT CAPITAL LLC | 49,600 | $1,708 |
| Campbell & CO Investment Adviser LLC | 44,394 | $1,531 |
| Jump Financial, LLC | 43,091 | $1,486 |
| Quantbot Technologies LP | 42,509 | $1,466 |
| PRELUDE CAPITAL MANAGEMENT, LLC | 40,135 | $1,384 |
| 125 other institutions | 1,380,909 | $44,783 |