LYELL IMMUNOPHARMA INC

Ticker: LYEL CUSIP: 55083R203 Class: Common Stock

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 15,616 Value ($000) $481 Avg Close $22.38 Range $15.62 - $45.00

Q3 2025

Shares 20,827 Value ($000) $338 Avg Close $11.42 Range $8.87 - $16.25

Q2 2025

Shares 10,059 Value ($000) $89 Avg Close $9.11 Range $7.65 - $13.80

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	15,616	$481	$22.38	$15.62 - $45.00
Q3 2025	20,827	$338	$11.42	$8.87 - $16.25
Q2 2025	10,059	$89	$9.11	$7.65 - $13.80