| ARCH Venture Management, LLC | 2,759,072 | $84,924 |
| GSK plc | 1,512,659 | $46,560 |
| MWG Caph Ltd | 1,008,116 | $31,030 |
| VANGUARD GROUP INC | 826,430 | $25,438 |
| Foresite Capital Management IV, LLC | 800,399 | $24,636 |
| Orland Properties Ltd | 754,698 | $23,230 |
| Almitas Capital LLC | 577,807 | $17,785 |
| Foresite Capital Management V, LLC | 477,078 | $14,684 |
| venBio Partners LLC | 337,697 | $10,394 |
| CITADEL ADVISORS LLC | 324,701 | $9,994 |
| Alphabet Inc. | 293,256 | $9,026 |
| BlackRock, Inc. | 181,837 | $5,597 |
| GEODE CAPITAL MANAGEMENT, LLC | 162,997 | $5,020 |
| HSG Holding Ltd | 152,299 | $3,935 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 151,016 | $4,648 |
| Invesco Ltd. | 98,649 | $3,036 |
| GOLDMAN SACHS GROUP INC | 96,675 | $2,976 |
| MIC Capital Management UK LLP | 87,028 | $2,679 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 85,423 | $2,629 |
| RBF Capital, LLC | 74,585 | $2,296 |
| MARSHALL WACE, LLP | 73,315 | $2,257 |
| MILLENNIUM MANAGEMENT LLC | 58,651 | $1,805 |
| JOHNSON & JOHNSON | 54,887 | $1,689 |
| STATE STREET CORP | 51,472 | $1,584 |
| MORGAN STANLEY | 42,949 | $1,322 |
| Ikarian Capital, LLC | 41,081 | $1,264 |
| RENAISSANCE TECHNOLOGIES LLC | 39,490 | $1,216 |
| CANADA PENSION PLAN INVESTMENT BOARD | 32,111 | $988 |
| NORTHERN TRUST CORP | 30,280 | $932 |
| Susquehanna Portfolio Strategies, LLC | 20,800 | $640 |
| Clarius Group, LLC | 19,958 | $614 |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 18,000 | $554 |
| BARCLAYS PLC | 15,967 | $491 |
| TWO SIGMA INVESTMENTS, LP | 15,616 | $481 |
| UBS Group AG | 13,203 | $406 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 13,128 | $0 |
| JANE STREET GROUP, LLC | 12,409 | $382 |
| Point72 Asset Management, L.P. | 11,480 | $353 |
| BOOTHBAY FUND MANAGEMENT, LLC | 9,516 | $293 |
| Qube Research & Technologies Ltd | 9,051 | $279 |
| ExodusPoint Capital Management, LP | 8,511 | $262 |
| BANK OF AMERICA CORP /DE/ | 8,045 | $248 |
| RAYMOND JAMES FINANCIAL INC | 7,900 | $243 |
| Candriam S.C.A. | 7,617 | $234 |
| CITIGROUP INC | 4,233 | $130 |
| China Universal Asset Management Co., Ltd. | 3,457 | $106 |
| BNP PARIBAS ARBITRAGE, SA | 3,170 | $98 |
| FMR LLC | 1,829 | $56 |
| ACADIAN ASSET MANAGEMENT LLC | 1,657 | $0 |
| JPMORGAN CHASE & CO | 1,616 | $50 |
| Tower Research Capital LLC (TRC) | 1,194 | $37 |
| Mirae Asset Global Investments Co., Ltd. | 1,031 | $32 |
| JONES FINANCIAL COMPANIES LLLP | 1,025 | $32 |
| Advisors Asset Management, Inc. | 567 | $17 |
| GF FUND MANAGEMENT CO. LTD. | 416 | $13 |
| WELLS FARGO & COMPANY/MN | 125 | $4 |
| OSAIC HOLDINGS, INC. | 124 | $4 |
| MAI Capital Management | 100 | $3 |
| US BANCORP \DE\ | 58 | $2 |
| Cornerstone Financial Management LLC | 46 | $1 |
| Daiwa Securities Group Inc. | 45 | $0 |
| SIMPLEX TRADING, LLC | 37 | $1 |
| GAMMA Investing LLC | 35 | $1 |
| NISA INVESTMENT ADVISORS, LLC | 25 | $1 |
| ROYAL BANK OF CANADA | 24 | $1 |
| CWM, LLC | 20 | $0 |