MBX BIOSCIENCES INC

Ticker: MBX CUSIP: 55287L101 Class: Common Stock

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 138,571 Value ($000) $4,371 Avg Close $24.26 Range $12.94 - $35.55

Q3 2025

Shares 13,587 Value ($000) $238 Avg Close $13.37 Range $9.63 - $26.47

Q1 2025

Shares 33,833 Value ($000) $250 Avg Close $10.57 Range $7.16 - $19.39

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	138,571	$4,371	$24.26	$12.94 - $35.55
Q3 2025	13,587	$238	$13.37	$9.63 - $26.47
Q1 2025	33,833	$250	$10.57	$7.16 - $19.39