| Frazier Life Sciences Management, L.P. | 6,652,013 | $209,804 |
| ORBIMED ADVISORS LLC | 3,935,203 | $124,116 |
| NEA Management Company, LLC | 3,614,486 | $114,001 |
| WELLINGTON MANAGEMENT GROUP LLP | 3,349,961 | $105,658 |
| Deep Track Capital, LP | 3,249,790 | $102,498 |
| BlackRock, Inc. | 2,919,756 | $92,089 |
| NVP Associates, LLC | 2,136,335 | $67,380 |
| EcoR1 Capital, LLC | 2,123,604 | $66,978 |
| VANGUARD GROUP INC | 1,817,811 | $57,334 |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,408,159 | $44,413 |
| Cormorant Asset Management, LP | 1,120,000 | $35,325 |
| BRAIDWELL LP | 1,018,600 | $32,127 |
| Woodline Partners LP | 1,000,063 | $31,542 |
| Kynam Capital Management, LP | 934,799 | $29,484 |
| EVENTIDE ASSET MANAGEMENT, LLC | 890,000 | $28,071 |
| Parkman Healthcare Partners LLC | 885,639 | $27,933 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 840,506 | $27 |
| CITADEL ADVISORS LLC | 809,857 | $25,543 |
| Point72 Asset Management, L.P. | 680,609 | $21,466 |
| STATE STREET CORP | 672,740 | $21,218 |
| D. E. Shaw & Co., Inc. | 671,838 | $21,190 |
| TCG Crossover Management, LLC | 650,000 | $20,501 |
| GEODE CAPITAL MANAGEMENT, LLC | 649,391 | $20,487 |
| MILLENNIUM MANAGEMENT LLC | 462,049 | $14,573 |
| Soleus Capital Management, L.P. | 408,900 | $12,897 |
| GOLDMAN SACHS GROUP INC | 331,938 | $10,469 |
| Trails Edge Capital Partners, LP | 315,158 | $9,940 |
| Rock Springs Capital Management LP | 282,624 | $8,914 |
| UBS Group AG | 281,212 | $8,869 |
| Opaleye Management Inc. | 260,000 | $8,200 |
| Affinity Asset Advisors, LLC | 250,000 | $7,885 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 222,180 | $7,008 |
| Goelzer Investment Management, Inc. | 221,672 | $6,992 |
| Elmind Capital, LP | 211,000 | $6,655 |
| NORTHERN TRUST CORP | 190,881 | $6,020 |
| Schonfeld Strategic Advisors LLC | 167,125 | $5,271 |
| DAFNA Capital Management LLC | 165,265 | $5,212 |
| Tetragon Partners GP Ltd | 143,327 | $4,521 |
| TWO SIGMA INVESTMENTS, LP | 138,571 | $4,371 |
| KVP Capital Advisors, LP | 121,524 | $3,833 |
| BALYASNY ASSET MANAGEMENT L.P. | 119,726 | $3,776 |
| TD Asset Management Inc | 101,450 | $3,200 |
| Burkehill Global Management, LP | 100,000 | $3,154 |
| JANE STREET GROUP, LLC | 86,581 | $2,731 |
| PFM Health Sciences, LP | 79,310 | $2,501 |
| STEMPOINT CAPITAL LP | 78,553 | $2,478 |
| OSAIC HOLDINGS, INC. | 77,601 | $2,447 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 76,528 | $2,414 |
| Nuveen, LLC | 75,565 | $2,383 |
| Bank of New York Mellon Corp | 75,262 | $2,374 |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 73,736 | $2,278 |
| Aaron Wealth Advisors LLC | 70,000 | $2,208 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 69,551 | $2,155 |
| MORGAN STANLEY | 59,026 | $1,862 |
| Verition Fund Management LLC | 57,575 | $1,816 |
| ExodusPoint Capital Management, LP | 57,005 | $1,798 |
| BARCLAYS PLC | 52,691 | $1,662 |
| ACADIAN ASSET MANAGEMENT LLC | 48,614 | $2 |
| Squarepoint Ops LLC | 46,702 | $1,473 |
| PLATINUM INVESTMENT MANAGEMENT LTD | 43,597 | $1,375 |
| BANK OF AMERICA CORP /DE/ | 37,894 | $1,195 |
| ALPS ADVISORS INC | 36,872 | $1,163 |
| Creative Planning | 33,651 | $1,061 |
| RHUMBLINE ADVISERS | 33,420 | $1,054 |
| RENAISSANCE TECHNOLOGIES LLC | 32,644 | $1,030 |
| WELLS FARGO & COMPANY/MN | 31,931 | $1,007 |
| AQR CAPITAL MANAGEMENT LLC | 31,409 | $991 |
| ALLIANCEBERNSTEIN L.P. | 27,900 | $880 |
| Brevan Howard Capital Management LP | 25,663 | $809 |
| Trexquant Investment LP | 24,268 | $765 |
| FOX RUN MANAGEMENT, L.L.C. | 23,820 | $751 |
| Qube Research & Technologies Ltd | 23,213 | $732 |
| Cerity Partners LLC | 21,323 | $673 |
| Invesco Ltd. | 21,203 | $669 |
| XTX Topco Ltd | 20,139 | $635 |
| DEUTSCHE BANK AG\ | 20,027 | $632 |
| GSA CAPITAL PARTNERS LLP | 19,295 | $1 |
| Koa Wealth Management, LLC | 18,413 | $581 |
| Seven Fleet Capital Management LP | 18,200 | $574 |
| CITIGROUP INC | 16,391 | $517 |
| MetLife Investment Management, LLC | 16,018 | $505 |
| FMR LLC | 15,746 | $497 |
| China Universal Asset Management Co., Ltd. | 15,317 | $483 |
| JPMORGAN CHASE & CO | 14,645 | $462 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 13,258 | $418 |
| AMERICAN CENTURY COMPANIES INC | 12,236 | $386 |
| CANADA PENSION PLAN INVESTMENT BOARD | 11,600 | $366 |
| Graham Capital Management, L.P. | 11,254 | $355 |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 10,360 | $226 |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 10,000 | $315 |
| GROUP ONE TRADING, L.P. | 9,428 | $297 |
| PROFUND ADVISORS LLC | 9,214 | $291 |
| SIMPLEX TRADING, LLC | 8,925 | $281 |
| Virtus Investment Advisers, LLC | 8,910 | $281 |
| Rafferty Asset Management, LLC | 8,113 | $256 |
| SEI INVESTMENTS CO | 7,657 | $242 |
| Police & Firemen's Retirement System of New Jersey | 7,520 | $237 |
| ProShare Advisors LLC | 7,187 | $227 |
| INTECH INVESTMENT MANAGEMENT LLC | 6,858 | $216 |
| BNP PARIBAS ARBITRAGE, SA | 6,784 | $214 |
| 36 other institutions | 44,540 | $1,166 |