MADRIGAL PHARMACEUTICALS INC

Ticker: MDGL CUSIP: 558868105 Class: EQTY

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q1 2023

Shares 24,292 Value ($000) $5,885 Avg Close $272.48 Range $222.87 - $313.93

Q4 2022

Shares 9,440 Value ($000) $2,740 Avg Close $97.80 Range $57.21 - $315.45

Q2 2021

Shares 68,235 Value ($000) $6,647 Avg Close $118.38 Range $95.21 - $142.62

Q1 2021

Shares 180,215 Value ($000) $21,080 Avg Close $116.59 Range $105.16 - $131.99

Q4 2020

Shares 76,111 Value ($000) $8,461 Avg Close $122.23 Range $107.55 - $137.28

Q3 2020

Shares 66,622 Value ($000) $7,910 Avg Close $108.57 Range $98.65 - $125.06

Q2 2020

Shares 77,342 Value ($000) $8,759 Avg Close $98.34 Range $56.82 - $127.25

Q1 2020

Shares 17,967 Value ($000) $1,199 Avg Close $83.31 Range $60.86 - $94.74

Q4 2019

Shares 2,250 Value ($000) $205 Avg Close $96.98 Range $82.31 - $121.21

Q3 2019

Shares 15,750 Value ($000) $1,358 Avg Close $93.82 Range $82.39 - $108.37

Q2 2018

Shares 13,549 Value ($000) $3,790 Avg Close $175.60 Range $98.81 - $325.98

Period	Shares	Value ($000)	Average Close	Price Range
Q1 2023	24,292	$5,885	$272.48	$222.87 - $313.93
Q4 2022	9,440	$2,740	$97.80	$57.21 - $315.45
Q2 2021	68,235	$6,647	$118.38	$95.21 - $142.62
Q1 2021	180,215	$21,080	$116.59	$105.16 - $131.99
Q4 2020	76,111	$8,461	$122.23	$107.55 - $137.28
Q3 2020	66,622	$7,910	$108.57	$98.65 - $125.06
Q2 2020	77,342	$8,759	$98.34	$56.82 - $127.25
Q1 2020	17,967	$1,199	$83.31	$60.86 - $94.74
Q4 2019	2,250	$205	$96.98	$82.31 - $121.21
Q3 2019	15,750	$1,358	$93.82	$82.39 - $108.37
Q2 2018	13,549	$3,790	$175.60	$98.81 - $325.98