| BAKER BROS. ADVISORS LP | 2,141,701 | $1,247,198 |
| RTW INVESTMENTS, LP | 1,993,687 | $1,161,004 |
| VANGUARD GROUP INC | 1,808,894 | $1,053,391 |
| Avoro Capital Advisors LLC | 1,807,500 | $1,052,580 |
| PAULSON & CO. INC. | 1,707,522 | $994,358 |
| BlackRock, Inc. | 1,644,750 | $957,803 |
| JANUS HENDERSON GROUP PLC | 1,584,843 | $918,204 |
| STATE STREET CORP | 583,003 | $339,506 |
| WELLINGTON MANAGEMENT GROUP LLP | 461,402 | $268,693 |
| GEODE CAPITAL MANAGEMENT, LLC | 451,743 | $263,114 |
| FMR LLC | 439,398 | $255,879 |
| BANK OF AMERICA CORP /DE/ | 416,025 | $242,268 |
| Invesco Ltd. | 365,314 | $212,737 |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 354,220 | $206,276 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 313,659 | $183 |
| GOLDMAN SACHS GROUP INC | 305,847 | $178,107 |
| Polar Capital Holdings Plc | 270,151 | $157,320 |
| ARMISTICE CAPITAL, LLC | 265,705 | $154,731 |
| Hood River Capital Management LLC | 247,560 | $144,164 |
| LORD, ABBETT & CO. LLC | 244,796 | $143 |
| ALKEON CAPITAL MANAGEMENT LLC | 240,000 | $139,762 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 219,099 | $127,590 |
| Artisan Partners Limited Partnership | 198,693 | $115,707 |
| NORGES BANK | 196,393 | $114,368 |
| DEUTSCHE BANK AG\ | 192,109 | $111,873 |
| AMERICAN CENTURY COMPANIES INC | 185,116 | $107,802 |
| Pictet Asset Management Holding SA | 181,949 | $106,018 |
| Fiera Capital Corp | 169,456 | $98,681 |
| NORTHERN TRUST CORP | 151,802 | $88,400 |
| MORGAN STANLEY | 150,462 | $87,620 |
| Erste Asset Management GmbH | 141,100 | $82,319 |
| Rock Springs Capital Management LP | 139,618 | $81,305 |
| Bank of New York Mellon Corp | 136,869 | $79,704 |
| Point72 Asset Management, L.P. | 126,435 | $73,628 |
| Woodline Partners LP | 125,659 | $73,176 |
| Nuveen, LLC | 118,363 | $68,928 |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 111,666 | $65,028 |
| UBS Group AG | 102,641 | $59,772 |
| MPM BioImpact LLC | 96,780 | $56,359 |
| JANE STREET GROUP, LLC | 93,114 | $54,224 |
| D. E. Shaw & Co., Inc. | 88,554 | $51,569 |
| FRANKLIN RESOURCES INC | 86,076 | $50,125 |
| Tri Locum Partners LP | 86,023 | $50,095 |
| RENAISSANCE TECHNOLOGIES LLC | 83,862 | $48,836 |
| ArrowMark Colorado Holdings LLC | 82,624 | $48,115 |
| NEW YORK STATE COMMON RETIREMENT FUND | 75,933 | $44,219 |
| Squarepoint Ops LLC | 74,934 | $43,637 |
| BNP PARIBAS ARBITRAGE, SA | 73,707 | $42,923 |
| First Light Asset Management, LLC | 66,831 | $38,918 |
| RAYMOND JAMES FINANCIAL INC | 66,724 | $38,912 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 64,466 | $37,541 |
| Voya Investment Management LLC | 64,254 | $37,418 |
| Candriam S.C.A. | 63,906 | $37,217 |
| Connor, Clark & Lunn Investment Management Ltd. | 58,295 | $33,948 |
| Jain Global LLC | 52,721 | $30,702 |
| Ensign Peak Advisors, Inc | 51,010 | $29,705 |
| Mirae Asset Global Investments Co., Ltd. | 50,631 | $29,484 |
| EULAV Asset Management | 49,000 | $28,535 |
| Russell Investments Group, Ltd. | 48,159 | $28,046 |
| CANADA PENSION PLAN INVESTMENT BOARD | 46,120 | $26,858 |
| WELLS FARGO & COMPANY/MN | 43,457 | $25,307 |
| JPMORGAN CHASE & CO | 40,079 | $23,340 |
| MARSHALL WACE, LLP | 39,578 | $23,048 |
| EMERALD ADVISERS, LLC | 38,913 | $22,661 |
| BARCLAYS PLC | 38,720 | $22,548 |
| CITADEL ADVISORS LLC | 36,134 | $21,042 |
| Atika Capital Management LLC | 34,000 | $19,800 |
| SEGALL BRYANT & HAMILL, LLC | 33,520 | $19,520 |
| GILDER GAGNON HOWE & CO LLC | 33,468 | $19,490 |
| Public Sector Pension Investment Board | 32,871 | $19,142 |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 31,286 | $18,219 |
| Affinity Asset Advisors, LLC | 31,131 | $18,129 |
| GROUPAMA ASSET MANAGMENT | 30,620 | $17,831 |
| AMERIPRISE FINANCIAL INC | 29,287 | $17,055 |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 29,051 | $16,958 |
| Swiss National Bank | 28,580 | $16,643 |
| STEADFAST CAPITAL MANAGEMENT LP | 26,850 | $15,636 |
| Rheos Capital Works Inc. | 26,215 | $15 |
| EMERALD MUTUAL FUND ADVISERS TRUST | 24,996 | $14,556 |
| FIRST TRUST ADVISORS LP | 24,819 | $14,453 |
| UBS ASSET MANAGEMENT AMERICAS INC | 23,846 | $13,886 |
| RHUMBLINE ADVISERS | 23,691 | $13,796 |
| CITIGROUP INC | 23,327 | $13,584 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 23,226 | $13,525 |
| SEI INVESTMENTS CO | 23,076 | $13,438 |
| ALLIANCEBERNSTEIN L.P. | 21,912 | $12,760 |
| Tao Capital Management LP | 21,000 | $12,229 |
| Rockefeller Capital Management L.P. | 19,661 | $11,449 |
| Rhenman & Partners Asset Management AB | 19,550 | $11,385 |
| DIMENSIONAL FUND ADVISORS LP | 19,321 | $11,251 |
| Jump Financial, LLC | 19,221 | $11,193 |
| Bridgewater Associates, LP | 19,218 | $11,191 |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 19,076 | $11,111 |
| NEUBERGER BERMAN GROUP LLC | 18,660 | $10,866 |
| STEMPOINT CAPITAL LP | 17,736 | $10,328 |
| WCM INVESTMENT MANAGEMENT, LLC | 17,254 | $10,072 |
| LPL Financial LLC | 16,542 | $9,633 |
| FEDERATED HERMES, INC. | 16,325 | $9,507 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 16,052 | $9,356 |
| ENVESTNET ASSET MANAGEMENT INC | 15,372 | $8,951 |
| 286 other institutions | 702,474 | $368,142 |