MADRIGAL PHARMACEUTICALS INC

Ticker: MDGL CUSIP: 558868105 Class: EQTY

Artisan Partners Limited Partnership's Holding History (CIK: 0001466153)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 198,693 Value ($000) $115,707 Avg Close $510.76 Range $393.61 - $615.00

Q3 2025

Shares 206,254 Value ($000) $94,600 Avg Close $373.08 Range $284.02 - $460.22

Q2 2025

Shares 201,571 Value ($000) $61,003 Avg Close $297.95 Range $265.00 - $349.00

Q1 2025

Shares 137,738 Value ($000) $45,623 Avg Close $328.59 Range $266.44 - $377.46

Q4 2024

Shares 207,469 Value ($000) $64,019 Avg Close $281.26 Range $200.63 - $368.29

Q3 2024

Shares 306,846 Value ($000) $65,119 Avg Close $255.83 Range $208.94 - $298.00

Q2 2024

Shares 345,085 Value ($000) $96,679 Avg Close $238.04 Range $189.00 - $295.50

Q1 2024

Shares 401,709 Value ($000) $107,272 Avg Close $235.62 Range $168.25 - $299.98

Q4 2023

Shares 296,480 Value ($000) $68,600 Avg Close $174.99 Range $119.76 - $245.31

Q3 2023

Shares 280,090 Value ($000) $40,904 Avg Close $188.22 Range $143.75 - $239.76

Q2 2023

Shares 230,090 Value ($000) $53,151 Avg Close $270.85 Range $192.22 - $322.67

Q1 2023

Shares 215,770 Value ($000) $52,272 Avg Close $272.48 Range $222.87 - $313.93

Q4 2022

Shares 212,290 Value ($000) $61,617 Avg Close $97.80 Range $57.21 - $315.45

Q3 2022

Shares 210,482 Value ($000) $13,679 Avg Close $69.48 Range $59.47 - $82.00

Q2 2022

Shares 211,719 Value ($000) $15,155 Avg Close $73.50 Range $57.15 - $100.90

Q1 2022

Shares 223,816 Value ($000) $21,961 Avg Close $84.31 Range $52.33 - $105.93

Q4 2021

Shares 219,884 Value ($000) $18,633 Avg Close $82.16 Range $68.56 - $102.42

Q3 2021

Shares 220,889 Value ($000) $17,625 Avg Close $86.38 Range $77.60 - $105.72

Q2 2021

Shares 220,687 Value ($000) $21,497 Avg Close $118.38 Range $95.21 - $142.62

Q1 2021

Shares 214,425 Value ($000) $25,081 Avg Close $116.59 Range $105.16 - $131.99

Q4 2020

Shares 210,380 Value ($000) $23,388 Avg Close $122.23 Range $107.55 - $137.28

Q3 2020

Shares 173,260 Value ($000) $20,571 Avg Close $108.57 Range $98.65 - $125.06

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	198,693	$115,707	$510.76	$393.61 - $615.00
Q3 2025	206,254	$94,600	$373.08	$284.02 - $460.22
Q2 2025	201,571	$61,003	$297.95	$265.00 - $349.00
Q1 2025	137,738	$45,623	$328.59	$266.44 - $377.46
Q4 2024	207,469	$64,019	$281.26	$200.63 - $368.29
Q3 2024	306,846	$65,119	$255.83	$208.94 - $298.00
Q2 2024	345,085	$96,679	$238.04	$189.00 - $295.50
Q1 2024	401,709	$107,272	$235.62	$168.25 - $299.98
Q4 2023	296,480	$68,600	$174.99	$119.76 - $245.31
Q3 2023	280,090	$40,904	$188.22	$143.75 - $239.76
Q2 2023	230,090	$53,151	$270.85	$192.22 - $322.67
Q1 2023	215,770	$52,272	$272.48	$222.87 - $313.93
Q4 2022	212,290	$61,617	$97.80	$57.21 - $315.45
Q3 2022	210,482	$13,679	$69.48	$59.47 - $82.00
Q2 2022	211,719	$15,155	$73.50	$57.15 - $100.90
Q1 2022	223,816	$21,961	$84.31	$52.33 - $105.93
Q4 2021	219,884	$18,633	$82.16	$68.56 - $102.42
Q3 2021	220,889	$17,625	$86.38	$77.60 - $105.72
Q2 2021	220,687	$21,497	$118.38	$95.21 - $142.62
Q1 2021	214,425	$25,081	$116.59	$105.16 - $131.99
Q4 2020	210,380	$23,388	$122.23	$107.55 - $137.28
Q3 2020	173,260	$20,571	$108.57	$98.65 - $125.06