MADRIGAL PHARMACEUTICALS INC

Ticker: MDGL CUSIP: 558868105 Class: EQTY

Brevan Howard Capital Management LP's Holding History (CIK: 0001512857)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 3,632 Value ($000) $2,115 Avg Close $510.76 Range $393.61 - $615.00

Q3 2025

Shares 1,375 Value ($000) $631 Avg Close $373.08 Range $284.02 - $460.22

Q2 2025

Shares 1,166 Value ($000) $353 Avg Close $297.95 Range $265.00 - $349.00

Q4 2024

Shares 1,001 Value ($000) $309 Avg Close $281.26 Range $200.63 - $368.29

Q4 2023

Shares 2,293 Value ($000) $531 Avg Close $174.99 Range $119.76 - $245.31

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	3,632	$2,115	$510.76	$393.61 - $615.00
Q3 2025	1,375	$631	$373.08	$284.02 - $460.22
Q2 2025	1,166	$353	$297.95	$265.00 - $349.00
Q4 2024	1,001	$309	$281.26	$200.63 - $368.29
Q4 2023	2,293	$531	$174.99	$119.76 - $245.31